甘草酸对芍药苷大鼠肠吸收的影响  

Influence of Glycyrrhizin on Intestinal Absorption of Paeoniflorin by the Everted Rat Gut Sac Model

作　　者：李娜[1,2] 陈西敬[1] 吴磊[1] 卢杨[1] 何焱[1] 苏云明[2] 

机构地区：[1]中国药科大学·药物代谢动力学研究中心,江苏南京210009 [2]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《时珍国医国药》2008年第12期2908-2909,共2页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.30472060);国家科技部“863”计划(No.2007AA02Z171)

摘　　要：目的研究甘草酸对芍药苷大鼠肠吸收的影响。方法采用大鼠肠外翻模型研究芍药苷的肠吸收,并用反相高效液相色谱法测定大鼠肠黏膜内外两侧的芍药苷浓度。结果芍药苷在大鼠十二指肠、空肠、回肠和结肠均有吸收,甘草酸几乎抑制芍药苷在各个肠段的吸收。结论甘草酸能减少大鼠肠吸收,机理可能是促进了芍药苷的外排或者促进了芍药苷在大鼠体内的转化。Objective To study the effects of glycyrrhizin on intestinal absorption of paeoniflorin by the evened rat gut sac model. Methods Used a simple RP - HPLC method for the determination of paeoniflorin in the Krebs fluid. Results Paeoniflorin could be absorbed in duodenum, jejunum, ileum and colon of rats, and glycyrrhizin could inhibit the absorption of paeoniflorin. Conclusion Glycyrrhizin can reduce the uptake of paconiflorin, and the mechanism is that it can improve the efflux from intestinal cells or the biotransformation of paeoniflorin.

关 键 词：芍药苷 甘草酸 肠外翻模型 

分 类 号：R285.5[医药卫生—中药学]