2-取代苯并咪唑合成工艺的改进  

An Improvement on Synthesis Process of 2-Subsitituted Benzimidazole

作　　者：唐欣[1,2] 唐有根[2] 刘小平[2] 蒋金芝[2] 

机构地区：[1]唯特偶化工开发实业有限公司,广东深圳518116 [2]中南大学化学化工学院,湖南长沙410083

出　　处：《广州化学》2008年第4期37-41,共5页Guangzhou Chemistry

摘　　要：以邻苯二胺和有机酸为原料,在磷酸和多聚磷酸混合酸的催化下合成了四种2-取代苯并咪唑化合物。利用红外光谱、核磁氢谱、熔点测定等方法对产物进行了结构表征。讨论了反应温度、催化剂用量对收率的影响。该合成工艺较原有的工艺得以完善,收率有较大提高。Under the catalysis of a mixture of polyphosphoric acid and phosphoric acid, four kinds of 2-subsitituted benzimidazole were synthesized from organic acid and o-diaminobenzene. The structures were characterized by IR, ^1H NMR, melting point analysis etc. Reaction temperature and catalysis content on the yield were discussed. The yield was higher by synthesis process improvement.

关 键 词：2-取代苯并咪唑 邻苯二胺 结构表征 工艺改进 

分 类 号：O626.23[理学—有机化学]