系统性红斑狼疮合并感染和病情活动时D-二聚体测定的临床意义  

The clinical significance of D-dimer in systemic lupus erythematosus flare and infection complications

作　　者：杨家良[1] 巩路[1] 袁双龙[1] 

机构地区：[1]天津医科大学总医院感染免疫科,天津300052

出　　处：《天津医科大学学报》2008年第4期507-509,共3页Journal of Tianjin Medical University

摘　　要：目的:了解无血栓形成或栓塞情况下系统性红斑狼疮(SLE)患者合并感染和病情活动时D-二聚体的水平及其临床价值。方法:测定91例SLE患者(合并感染组30例、病情活动组33例、病情稳定组28例)血浆D-二聚体水平的差异,与非特异性炎症指标血沉(ESR)的关系及治疗前后的变化。结果:(1)合并感染SLE患者血浆D-二聚体水平明显高于病情活动期患者(均P<0.01),病情活动组与病情稳定组患者D-二聚体水平也有明显差异(P<0.01);(2)合并感染组和病情活动组D-二聚体与ESR均成呈正相关(P<0.01,P<0.05);(3)治疗后血浆D-二聚体水平较治疗前明显降低(P<0.01)。结论:血浆D-二聚体可以作为非特异性炎症指标用于SLE炎症活动、感染和临床疗效的评估,感染和炎症活动可能影响D-二聚体在血栓形成或栓塞诊断中的敏感性。Objective： To evaluate clinical significance of plasma D-dimer in systemic lupus erythematosus （SLE） without thrombosis or embolism. Methods： The levels of plasma D-dimer in 91 SLE patients including infection groups, disease flare groups and disease inactivity groups were measured to see the difference of them and the correlation to ESR. Results： The levels of D-dimer in infection groups were significantly higher than those in disease flare groups and disease inactivity groups （P〈0.01）.There was significant diversity between disease flare groups and disease inactivity groups（P〈0.01）. There was a positive correlation between levels of plasma D-dimer and ESR in infection groups （P〈0.01）and disease flare groups （P〈0.05）. The levels of plasma D-dimer were significantly decreased （P〈0.01）in 12 patients after the treatment. Conclusion： Levels of plasma D-dimer is valuable for assessment of infection complications and disease relapse and rapeutic effect in SLE.Infection and inflammatory activity may effect on the sensitivity of D-dimer in the diagnosis of thrombosis or embolism.

关 键 词：D-二聚体 红斑狼疮 系统性 感染 

分 类 号：R593.241[医药卫生—内科学]