丹参酮对寻常性痤疮皮损组织β防御素-2 mRNA表达的影响  

The Effect of Tanshinone on Expression of Human β-defensin-2 in Acne Vulgaris

作　　者：曾慧明[1] 戴永江[1] 林岷格[1] 邓斌[1] 

机构地区：[1]海南医学院附属医院皮肤科,海南海口570102

出　　处：《中国皮肤性病学杂志》2008年第12期707-708,717,共3页The Chinese Journal of Dermatovenereology

基　　金：海南省卫生厅课题(编号:琼卫2005-55号)

摘　　要：目的探讨寻常性痤疮皮损中人β防御素-2(HBD-2)mRNA的表达情况及丹参酮对其的影响。方法选择40例寻常性痤疮患者于口服丹参酮治疗前、后分别评价疗效及不良反应,同时取背部皮损,用逆转录聚合酶链反应法(RT-PCR)检测HBD-2 mRNA的表达情况,并与20名健康人进行比较。结果治疗组治疗前、后皮损及正常对照组均可检测到HBD-2 mRNA的表达,患者皮损部位表达明显高于非皮损部位和对照组,差异有显著性意义(P<0.01),治疗后患者皮损中HBD-2 mRNA表达比治疗前显著下降(P<0.01),但明显高于非皮损部位和正常对照组(P<0.01)。治疗后患者非皮损部位HBD-2 mRNA表达较治疗前升高(P<0.05)。结论丹参酮有抗炎、杀菌的功能,还可保持患者皮损局部HBD-2 mRNA的较高浓度表达,增强对寻常性痤疮患者的抗炎作用。Objective To investigate the effects of Tanshinone on the expression of human β defensin-2 （HBD-2） in the lesional skin of ache vulgaris. Methods The expression of HBD-2 in the lesional skin of 40 acne vulgaris patients （before and after the treatment） and 20 normal controls were detected by RT-PCR. Results Tanshinone was more effective on the comedo and papule lesions of acne. Expression of HBD-2 could be detected in all samples. The expression level of HBD-2 in lesional skin was sig- nificantly than that in the non - lesional skin and normal controls. In lesional skin HBD-2 expression was decreased after therapy, while still higher than that in non-lesional skin and normal controls. Conclusion Tanshinone therapy can maintain the high expression level of HBD-2 in the lesional skin of acne vulgaris, and provide anti-inflammatory enhancement potence.

关 键 词：痤疮 寻常性 丹参酮 人Β防御素-2 

分 类 号：R758.73[医药卫生—皮肤病学与性病学]