置换肽对豚鼠银屑病样模型血清IFN-γ的抑制作用  

Depressant Effect of APL on IFN-γ of Psoriasis-like Model of Guinea pig

作　　者：史晓蔚[1] 沈柱[1] 王刚[1] 李红[1] 刘玉峰[1] 

机构地区：[1]第四军医大学西京医院全军皮肤病研究所,陕西西安710032

出　　处：《中国皮肤性病学杂志》2008年第12期723-725,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的探讨置换肽(APL)对豚鼠银屑病样模型血清IFN-γ浓度的影响。方法采用心得安法制备豚鼠耳廓银屑病样模型,APL组和对照组皮损处分别外涂APL及对照药物,ELISA法检测血清IFN-γ变化,分析涂药前、后各组内及组间的差异。结果APL组动物血清IFN-γ表达量明显低于对照组(P<0.05),高浓度的APL对IFN-γ的抑制作用更强。结论提示APL对豚鼠银屑病样模型血清IFN-γ的表达具有抑制作用。Objective To investigate the effect of APL on IFN-γ of psoriasis-like model of guinea pig. Methods Propranolol was applied to make the psoriasis-like model of guinea pig. We topically applied APL and control medicines on the ears of guinea pig and detected the expression of IFN-γ by ELISA method. We analyzed the variability of the concentration of IFN-γ, in groups before and after using medicines. Results The expression of IFN-γ of guinea pig in APL groups was lower than that of the controls （P 〈 0.05）. The higher concentration of APL could suppress IFN-γ more. Conclusion It suggested that APL had the depressant effect on psoriasis - like model of guinea pig.

关 键 词：置换肽 IFN-Γ 银屑病 动物模型 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]