子痫前期及子痫患者血小板活化和肝肾功能检测的意义  

Significance of the activation of blood platelet and hepatic and renal function in patients with pre-eclampsia and eclampsia

作　　者：廖琪[1] 马晓艳[1] 郑明阳[1] 崔满华[1] 苏学金[2] 

机构地区：[1]吉林大学第二临床医院妇产科,长春130041 [2]吉林大学基础医学院教育部分子病理重点实验室

出　　处：《中国医师进修杂志》2008年第12期11-14,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：目的通过检测子痫前期及子痫患者血中血小板膜糖蛋白（GP）Ⅱb/Ⅲa、Pt和肝肾功能指标，以探讨血小板活化因子及肝肾功能指标在子痫前期及子痫中的变化及意义。方法分别检测子痫前期及子痫（子痫前期-子痫组，60例；其中轻度子痫前期组22例，重度子痫前期-子痫组38例）、正常孕晚期（正常孕晚期组，30例）、正常未孕妇女（正常未孕组，20例）GPⅡb，Ⅲa、Pt和肝肾功能指标。结果GPⅡb，Ⅲa：重度子痫前期-子痫组与正常未孕组、正常孕晚期组、轻度子痈前期组比较差异均有统计学意义（P〈0．01）。Pt：重度子痫前期-子痫组比正常未孕组、正常孕晚期组、轻度子痫前期组均明显降低，差异有统计学意义（P〈0．01）。除ALB外，重度子痫前期一子痫组肝肾功能指标与正常孕晚期组、轻度子痫前期组比较差异均有统计学意义。结论联合检测GPⅡb，Ⅲa、Pt和肝肾功能指标，对重度子痫前期及子痫患者诊断血小板活化、肝肾脏器损害有重要临床意义。Objective To discuss the role of platelet-actived factors and hepatic and renal function in the development of pre-eclampsia and eclampsia by detecting the levels of the GP Ⅱ b/Ⅲ a in the blood, Pt and hepatic and renal function of the patients with pre-eclampsia and eclampsia. Method GP Ⅱ b/Ⅲ a, Pt and hepatic and renal function were measured in the normal non-pregnancy women, normal late-pregnancy women and pre-eclampsia and eclampsia women. Results The level of GP Ⅱ b/Ⅲ a in patients with severe pre-eclampsia and eclampsia was higher than that in non-pregnancy, normal late-pregnancy and mild pre-eclampsia （P 〈 0.01 ）. The count of Pt in patients with severe pre-eclampsia and eclampsia was lower than that in non-pregnancy, normal late-pregnancy and mild pre-eclampsia （P 〈 0.01 ）. Except ALB, the hepatic and renal function had significant difference among severe pre-eclampsia and eclampsia, normal late-pregnancy and mild pre-eclampsia. Conclusion Detecting the GP Ⅱ b/Ⅲ a, Pt and hepatic and renal function have chnical significance in severe pre-eclampsia and eelampsia.

关 键 词：血小板膜糖蛋白类 受体 纤维蛋白原 子痫 

分 类 号：R714[医药卫生—妇产科学]