7-TMCA盐酸盐的合成与分析  

Synthesis and Analysis of 7-TMCA·HCl

作　　者：高晓荣[1] 魏文珑[2] 张斌 李俊波[4] 常宏宏[2] 

机构地区：[1]太原科技大学化学与生物工程学院,山西太原030021 [2]太原理工大学化学化工学院,山西太原030024 [3]神华准格尔能源有限公司发电厂,内蒙古鄂尔多斯010300 [4]长治医学院药学系化学教研室,山西长治046000

出　　处：《化工时刊》2008年第12期23-25,共3页Chemical Industry Times

摘　　要：对头孢类药物中间体7-TMCA盐酸盐的合成工艺进行了研究。以1-甲基-5-巯基四氮唑和7-ACA为原料,三氟化硼乙腈配合物为催化剂合成了7-TMCA盐酸盐,反应收率可达91.80%.产物经熔点、IR分析确定了结构,对7-TMCA盐酸盐的HPLC分析方法进行了研究,运用该法分析条件按面积归一法测得合成产物含量为99.33%。The synthesis technology of 7-TMCA·HCl was studied,which was intermediate of cephalosporins.with 1-methylte-trazole-5-thiol and 7-ACA as the material and acetonitrile-boron trifluoride complex as Catalysts,7-TMCA·HCl was preparated and the yield could reach 91.80%.The product structure was confirmed by melting points and IR spectra.Research on HPLC analysis method for 7-TMCA·HCl,under which,its content was measured to be 99.33% by the area normalization method.

关 键 词：7-TMCA盐酸盐 三氟化硼乙腈配合物 合成 分析 

分 类 号：TQ463.5[化学工程—制药化工]