息斯敏对大鼠心肌电生理参数的影响  

The Effect of Hismanal on Electrophysiological Parameters of Cardiac Muscle in Rat

作　　者：郑卫红[1] 

机构地区：[1]三峡大学医学院药理学教研室,宜昌443002

出　　处：《实用医学进修杂志》2008年第4期227-230,共4页Journal of Practical Training of Medicine

基　　金：湖北省教育厅自然科学研究基金青年项目（Q200613003）

摘　　要：目的：通过观察息斯敏对大鼠离体心肌自律性、兴奋性和有效不应期的作用，了解其对心肌电生理特性的影响，以初步探索其心脏作用机理。方法：将心房肌和心室乳头肌标本置于盛有Tyrode’s液的恒温器官浴槽中，向浴槽中累积加入息斯敏。记录右心房一窦房结的自发频率，测定左心房与乳头肌收缩的阈刺激电压值和有效不应期。结果：息斯敏能减慢窦房结自发频率，降低心肌自律性；能增加引起心房肌和心室乳头肌收缩的阈刺激电压值，降低心肌兴奋性；能使心房肌和心室乳头肌的有效不应期明显延长。结论：息斯敏能干扰心肌正常电生理特性，对心肌电生理活动具有抑制作用。Objective： To explore the mechanism of caraiac action of hismanal initially through observing the effect of hismanal on the isolated myocardial autorhythmicity, excitability, effective refractory period （ERP） of rat and getting the message about its action on electrophysiological characteristics of cardia muscle. Methods： The cardiac atrium muscle and papillary muscle preparation were placed into organ bath with constant temperature Tyrodc＇ s solution. Then plus hismanal to it and record the spontaneous frequency of right atrium-sinoatrial node and detect the voltage value of threshold stimulus that cause atrium and ventricle papillary muscle contraction and their ERP. Results： Hismanal could step down the frequency of right atrium-sinoatrial node, raise the voltage value of threshold stimulus and prolong ERP of atrium and papillary muscle. Conclusions： Hismanal could inhibit the electrophysiological activity of cardia muscle through interfering its normal electrophysiology characteristics.

关 键 词：息斯敏 心肌 电生理特性 

分 类 号：R541.4[医药卫生—心血管疾病] R976[医药卫生—内科学]