血清肌钙蛋白Ⅰ与慢性心力衰竭患者室性心律失常的关系  

Relationship between Serum Cardiac Troponin I and Ventricular Arrhythmia in Patients with Chronic Heart Failure

作　　者：谭维羚[1] 钟志英[1] 孙国锋[1] 周宇昕[1] 

机构地区：[1]南昌大学第四附属医院心血管内科,南昌330003

出　　处：《实用临床医学（江西）》2008年第11期9-11,共3页Practical Clinical Medicine

摘　　要：目的探讨慢性心力衰竭(chronic heart failure,CHF)患者血清心肌肌钙蛋白Ⅰ(cardiac troponinI,cTnI)与室性心律失常的关系。方法根据入院时血清cTnⅠ检测结果将218例CHF患者分为cTnⅠ阳性组(cTnⅠ≥0.05 ng/mL)108例和cTnⅠ阴性组(cTnⅠ<0.05 ng/mL)110例。2组患者均行24 h动态心电图监测。结果cTnⅠ阳性组平均每小时单个室性异位搏动的个数、平均每小时成对室性异位搏动的个数、24 h室性心动过速的次数均明显高于cTnI阴性组(P均<0.05)。多变量logistic回归分析结果显示,cTnⅠ阳性是CHF患者室性心律失常的预测因子。结论cTnⅠ阳性与CHF患者室性心律失常密切相关。Objective To elucidate the relationships between serum cardiac troponin I（cTnI） and ventricular arrhythmia in patients with chronic heart failure（CHF）. Methods Two hundred and eighteen patients with CHF were divided into two groups： cTnI-positive group with serum cTnI≥0.05 ng/mL（n= 108） and cTnI-negative group with serum cTnI〈0.05 ng/mL（n= 110）. The assessed by 24 h Holter monitoring in two groups. Results The cTnI-positive group number of mean hourly ventricular pairs, mean hourly number of single ventricular ectopic beats and the frequency of ventricular tachycardia episodes per 24 h were higher in cTnI-negative group（all P〈0.05）. In multivariate logistic regression, cTnI-positive could be a predictor of ventricular arrhythmias in CHF patients. Conclusion cTnI-positive closely related with ventricular arrhythmia in CHF patients.

关 键 词：心肌肌钙蛋白I 慢性心力衰竭 室性心律失常 

分 类 号：R541.7[医药卫生—心血管疾病]