维生素C对慢性肾衰竭患者的氧化应激状态的影*响  

The effect of oxidative stress on Vitamin C in chronic renal failure

作　　者：林淑华[1] 孙芳[1] 滕舰[1] 

机构地区：[1]烟台市烟台山医院,山东烟台264001

出　　处：《泰山医学院学报》2008年第8期571-572,共2页Journal of Taishan Medical College

摘　　要：目的探讨维生素C对慢性肾衰竭(CRF)患者氧化应激的影响。方法CRF患者60例,随机分为维生素C治疗组(30例)对照组(30例),健康志愿者30例为正常对照组。治疗组静脉维生素C 500 mg/d 8周。观察用药前后血浆丙二醛(MDA)、还原型谷胱甘肽(GSH)氧化应激变化。结果治疗前慢性肾衰竭患者与正常对照组比较,血浆MDA水平明显较高,GSH水平明显较低(P<0.01)。治疗后,维生素C治疗组与治疗前比较,MDA水平明显下降,GSH水平明显提高(P<0.01);与对照组比较,GSH水平明显提高(P<0.05)。结论维生素C可有效减轻CRF患者氧化应激状态。Objective： The effect of oxidative stress on Vitamin C in chronic renal failure（CRF）.Methods： 60 CRF patients were randomly divided into treatment group（n=30） and control group（n=30）.thirty healthy volunteers were in normal control.Treatment group treated by vitamin C 500mg/d for 8 weeks.Malondialdehyde（MDA）,Glutathione（GSH） in plasma were measured at the beginning and the end of the study.Results： MDA in plasma was significantly higher in CRF compared with that in healthy（P〈0.01）.GSH in plasma was lower than that in healthy（P〈0.01）;8 weeks later,MDA was lower,GSH was significantly higher than before treatment in group VC.GSH was significantly higher in VC group than control group.Conclusion： Vitamin C may alleviate the oxidative stress of CRF.

关 键 词：慢性肾衰竭 维生素C 氧化应激 

分 类 号：R692.5[医药卫生—泌尿科学]