东海县麻疹疫苗效价及基础免疫成功率监测分析  

Surveillance of Measles Vaccine Botency and the Success Rate of Basic Immunization in Donghai County

作　　者：张振宇[1] 陈晓芹[1] 葛恒明 尚红梅[1] 朱莲[1] 孙和平[1] 

机构地区：[1]东海县疾病预防控制中心,江苏东海222300

出　　处：《中国初级卫生保健》2008年第12期38-39,共2页Chinese Primary Health Care

摘　　要：目的考核和评价东海县儿童麻疹疫苗的接种质量和效果,了解冷链系统和疫苗管理情况。方法2006年对东海县63名满8月龄儿童于麻疹疫苗免疫前及免疫后1个月各采集末梢血0.5ml,分离血清,应用血凝抑制试验检测麻疹血凝抑制(HI)抗体。采用组织培养法检测县疾控中心和乡镇接种点麻疹疫苗效价。结果免疫前麻疹HI抗体阳性率为6.35%,免疫后为100%,基础免疫成功率为96.83%,免疫后麻疹HI抗体几何平均滴度为1∶122.49。县疾控中心和乡镇接种点麻疹疫苗效价均在102.5TCID50/0.lmL以上,均为合格疫苗。结论东海县麻疹疫苗基础免疫成功率为96.83%,高于国家免疫规划规定的免疫成功率≥85%的指标,冷链系统和疫苗管理情况良好,为控制和消除麻疹奠定良好的基础。OBJECTIVE To assess and evaluate the immunization quality and effectiveness of measles vaccine in Donghai County, and understand of the cold chain system and the management of vaccine. METHODS Collected Peripheral blood 0.5 ml respectively from 63 children who were eight months old enough before and later one month they got vaccinated measles vaccine in 2006, and separated of serum, and applied Hemagglutination Inhibition （HI）test to survey the HI autibody of measles .Used tissue culture way to detecte the measles vaccine potency of county CDC and township vaccination points. RESULTS Before vaccinated measles vaccine, the positive rate of HI antibody was 6.35%, and after was 100%, the success rate of basic immunization was 96.83%, the geometric mean titer of HI antibody was 1：122.49. The Measles vaccine potency of county CDC and township vaccination points were above 10^2.5CID50/0.1 mL, and all were qualified vaccine. CONCLUSIONS The success rate of the measles vaccine basic immunization was 96.83%, more than 85% which was the success rate of immunization of state. Vaccines and cold chain management system were in good condition, which laid a good foundation for controlling and eliminating measles.

关 键 词：麻疹疫苗 疫苗效价 麻疹HI抗体 基础免疫成功率 

分 类 号：R186[医药卫生—流行病学]