乙型肝炎病毒转录后调节元件的研究进展  

An Overview of HBV Posttranscriptional Regulatory Element

作　　者：程丽英[1] 黄爱龙[1] 汤华[1] 

机构地区：[1]重庆医科大学感染性疾病分子生物学教育部重点实验室,重庆400016

出　　处：《生物技术通报》2008年第6期56-59,64,共5页Biotechnology Bulletin

摘　　要：乙型肝炎病毒(Hepatitis B virus,HBV)转录后调节元件(HBV posttranscriptional regulatory element,HPRE)是位于HBV基因组内的一段调控序列。因其在转录后水平调节HBV的基因表达而命名。它对HBV基因的高表达是非常重要的。自从1993年被发现后,它的功能机制及与其相互作用的蛋白因子一直是人们的研究热点,为深入研究HBV基因表达的调控机制创造了条件。同时,这些研究可能促进下调病毒基因表达的新的机制的形成,为防治HBV感染的相关疾病奠定了基础。HPRE,as posttranscriptional regulatory element within hepatitis B virus genome,play an important role in regulating expression of HBV gene at posttranscriptional level.Since it was found in 1993,associated functional mechanism of HPRE and protein factors have been on research focus.These studies laid conditions for further research of HBV gene expression regulatory mechanism,and also in the hope that these researches could facilitate the formulation of new strategies to down-regulate viral gene expression and hence prevent HBV-associated diseases.An overview of study on HPRE was given in this paper.

关 键 词：乙肝病毒 乙肝病毒转录后调节元件 转录后调节 蛋白因子 相互作用 

分 类 号：R373[医药卫生—病原生物学]