扶正合剂改善乳腺癌患者化疗副作用的临床观察  

Observation of Fuzheng Composition improving side effect of chemotherapy in patients with breast tumor

作　　者：贾文娟[1] 邢秀玲[1] 贾英杰[2] 田菲（指导老师） 

机构地区：[1]天津中医药大学2006级硕士研究生,天津300193 [2]天津中医药大学第一附属医院肿瘤科,天津300193 [3]不详

出　　处：《河北中医》2008年第11期1141-1142,1148,共3页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的观察扶正合剂改善乳腺癌患者化疗副作用的临床疗效。方法将60例乳腺癌化疗患者随机分为2组。治疗组30例在化疗期间配合服用扶正合剂,对照组单纯予化疗。结果治疗组第2、3周期症状评分明显降低,与本组治疗前比较差异均有统计学意义(P<0.01);对照组第2、3周期症状评分均明显升高,与本组治疗前比较差异均有统计学意义(P<0.01);2组治疗后同周期比较差异有统计学意义(P<0.01)。治疗组治疗后生存质量评分升高,而对照组生存质量评分下降,与本组治疗前比较差异均有统计学意义(P<0.05,P<0.01);2组治疗后同周期比较差异均有统计学意义(P<0.01)。2组治疗后白细胞下降分级及恶心呕吐分级比较差异均有统计学意义(P<0.05);对照组治疗后CD3、CD4下降,与本组治疗前比较差异有统计学意义(P<0.05);2组治疗后癌胚抗原(CEA)、血清糖蛋白抗原153(CA153)与本组治疗前及2组治疗后比较差异均有统计学意义(P<0.05)。结论扶正合剂能改善患者化疗期间出现的临床症状,提高生存质量,减轻白细胞下降及胃肠道反应,并能保护机体免疫功能,抑制病情进展。Objective To observe Fuzheng Composition improving side effect of chemotherapy in patients with breast tumor. Methods 60 patients with breast tumor were randomly divided into two groups. Patients in treatment group （ n = 30） received Fuzheng Composition in period of chemotherapy. Patients in control group （ n = 30） were treated by only chemotherapy. Results Symptom score of third and fourth period in treatment group was lower than that in control group after treatment （ P 〈 0.01）. Life quality score in treatment group was higher than that in control group after treatment （ P 〈 0.01 ）. Classes of leukocyte degression and nausea and vomiting in treatment group were superior to those in control group （ P 〈 0.05）. There was difference between two groups in CEA and CA15 - 3 after treatment （ P 〈 0.05）. Conclusion Fuzheng Composition can improve side effect of chemotherapy in patients with breast tumor, raise life quality, relieve leukocyte decrease and gastrointestinal reaction and protect immune function.

关 键 词：乳腺肿瘤 抗肿瘤联合化疗方案 毒性作用 中药疗法 汤剂 

分 类 号：R283.6[医药卫生—中药学] R737.905.3[医药卫生—中医学]