活血通脉灵对心肌缺血大鼠血脂、心电图、心肌组织病理学改变的影响  

Effect of HXTML on myocardial ischemic rats

作　　者：高绍芳[1] 李佃贵[2] 贾艳素 

机构地区：[1]河北医科大学研究生学院,河北石家庄050011 [2]河北省中医院,河北石家庄050011 [3]河北省石家庄卫生学校临床部,河北石家庄050200

出　　处：《河北中医》2008年第11期1210-1212,F0003,共4页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的探讨活血通脉灵对实验性心肌缺血大鼠心肌损伤的抗炎保护作用机制。方法将50只Wistar雄性大鼠随机分为5组,即空白对照组、模型对照组、药物对照组及活血通脉灵大剂量组和活血通脉灵小剂量组各10只。空白对照组以普通饲料喂养,其余各组均以高脂饲料喂养,形成高脂血症模型,随后灌胃用药。空白对照组和模型对照组给予0.9%氯化钠注射液10 mL/kg;药物对照组给予消心痛2.5 mg/kg;活血通脉灵大剂量组和小剂量组分别给予含生药472、3.5 g/kg汤剂,自末次给药前3日,除空白对照组外,其余4组均于灌胃给药30 min后皮下注射异丙肾上腺素,形成心肌缺血的复合模型,空白对照组皮下注射等容积0.9%氯化钠注射液。观察各组血脂[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]、心电图(ST段、T波)及心肌组织的病理学改变。结果活血通脉灵能降低TG、TC、LDL-C,升高HDL-C;改善ST段及T波压低;保护缺血心肌。结论活血通脉灵对大鼠心肌缺血而引起的心肌损伤具有保护作用,并能降低血脂,改善心肌供血。Objective To study the protective effects and mechanism of HuoxueTongluoling （HXTML） on experimental myocardial ischemic rats. Methods 50 healthy male Wister rats were randomly divided into five groups namely blank group, model group, Cedocard group, HXTML high dose and HXTML low dose group, 10 rats in each group. Each rat had been recorded Ⅱ electrocardiography （ECG） before the experiment. Hyperlipemic forage was feed and Isoproterenol （ISO） was subcutaneously injected into rats except Blank group to cause myocardial ischemia., ECG,blood fat and Myocardial tissue were detected by modem medical method after treatment. Results HXTML significantly decrease riG, TC and LDL- C; and significantly increase HDL- C, improve ST stage and T wave in ECG. Conclusion HXTML can alleviate the myocardial damage and protect myocardial tissue of rots. Furthermore, it has some particular effects on blood fat decrease.

关 键 词：心肌缺血 高脂血症 异丙肾上腺素 心血管药物(中药) 胆固醇 疾病模型 动物 药理学 

分 类 号：R452[医药卫生—治疗学] R541.41[医药卫生—临床医学]