扑热息痛多腔体贮库式植入剂的制备及体外释放性能检测  

Preparation of Paracetamol multiloculated implant and its drug release profile in vitro

作　　者：李维凤[1] 王小鹏[2] 牛晓峰[1] 刘燕玲[1] 范特[1] 

机构地区：[1]西安交通大学医学院药学系,陕西西安710061 [2]西安交通大学机械工程学院,陕西西安710049

出　　处：《西安交通大学学报（医学版）》2008年第6期640-643,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家863计划基金资助项目(No.2006AA04Z330);国家自然科学基金资助项目(No.50705074)

摘　　要：目的以聚乳酸-羟基乙酸共聚物(PLGA)为载体,制备扑热息痛贮库式缓释体系,研究其体外释药性能。方法用微机电技术制备扑热息痛多腔体贮库式植入剂,采用高效液相色谱法检测药物的释放性能。本实验采用C18色谱柱,以甲醇-水(15∶85)为流动相,检测波长为215nm,流速为0.8mL/min。结果载体形状不同,体外药物释放速率具有明显差异,外方内六边形扑热息痛植入剂缓释曲线符合Higuchi方程。结论扑热息痛多腔体贮库式植入剂制备工艺可行,载体的腔体形状对体外药物释放速度有较大影响。Objective To prepare Paracetamol （APP） multiloculated implant loaded with poly-lactide-coglycolide acid （PLGA） and to study the drug release profile in vitro. Methods APP multiloculated implant was fabricated by micro-electro-mechanical system （MEMS）, and high-performance liquid chromato graphy （HPLC） measurement was used to investigate in vitro drug release profile. HPLC analysis was carried out by employing C18 column and a mixture of methanol-water （15 ： 85） as mobile phase. The detection wavelength was 215 nm and flow rate was 0.8 mL/min. Results With different multiloculated shape, the rate of the drug release in vitro was varied significantly. Moreover, the releasing of APP multiloculated implant with ecto-tetragonum ento-hexagon in vitro conformed to Higuchi equation. Conclusion The technology of the preparations is feasible, and the structural and morphological characteristics of the multiloculated implant have a significant impact on the release speed of the drug delivery system.

关 键 词：扑热息痛 聚乳酸-羟基乙酸共聚物 多腔体植入剂 体外释放 

分 类 号：R943[医药卫生—药剂学] R927.1[医药卫生—药学]