行气活血饮对慢性乙型肝炎肝纤维化肝郁脾虚证患者铁代谢的影响  

Effects of decoction of promoting Qi and activate blood on iron metabolism in patient with chronic hepatitis B and liver fibrosis due to stagnation of liver-QI and spleen deficiency

作　　者：陈黎[1] 蒋阳昆[1] 张红星[1] 林海[1] 黄彬[1] 

机构地区：[1]广西中医学院附属瑞康医院肝胆内科,广西南宁530011

出　　处：《中西医结合肝病杂志》2008年第6期327-329,361,共4页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:观察行气活血饮对慢性乙型肝炎肝纤维化肝郁脾虚证患者铁代谢的影响。方法:65例患者随机分为两组,治疗组34例,对照组31例,治疗组患者用行气活血饮治疗,对照组患者口服复方丹参片。观察比较患者治疗前后血清透明质酸、Ⅲ型前胶原、IV型胶原、层粘连蛋白变化及血清铁、铁蛋白、转铁蛋白水平变化。结果:治疗组患者治疗后血清透明质酸、IV型胶原、血清铁、血清铁蛋白水平较治疗前下降,两组相比差异有显著性意义。治疗组总有效率为85.3%,显著高于对照组58.1%(P<0.05)。结论:行气活血饮有一定的抗肝纤维化作用,对血清铁、血清铁蛋白有显著抑制作用。Objective： To observe the effects of decoction of promoting Qi and activate blood to the iron metabolism of stagnation of liver-QI with deficiency of the spleen in liver fibrosis with chronic hepatitis B patients. Methods： Sixty and five patients with stagnation of liver-QI with deficiency of the spleen in liver Fthrosis with chronic hepatitis B were randomly divided into 2groups, namely treatment group （34 cases） and control group （31cases） . Treatment group was orally administrated with decoction of promoting Qi and activate blood. The control group was orally treated with tablet compound Red-rooted Salvia. Serum hyaluronic acid （HA）, serum procollagen type Ⅲ （PCⅢ）, collagen type Ⅳ （ColⅣ）, serum laminin （LN）, serum iron, serum ferritin, serum transferrin were observed to evaluate the effects of the Chinese herb therapy to the liver fibrosis. Results： The level of serum HA, ColIV, serum iron, serum ferritin in treatment group were significantly get down compared with control group. The total effective rate was 85.3% that markedly higher than that the 58. 1% of control group （P 〈0. 05） . Conclusion： The decoction of promoting Qi and activate blood have some extent of anti-liver fibrosis effect and can significantly inhibit the levels of serum iron, serum ferritin.

关 键 词：煎剂 行气 活血 治疗 肝纤维化 

分 类 号：R259[医药卫生—中西医结合]