北京地区汉族人FGF23基因SNP与青年女性峰值骨量和血磷的关系  

Association of SNP of FGF23 Gene with peak bone mass and serum phosphorus in 202 young women of the Han nationality in Beijing area

作　　者：庞莉[1] 夏维波[1] 龚凤英[1] 李梅[1] 邢小平[1] 王鸥[1] 姜艳[1] 徐苓[1] 孟迅吾[1] 周学瀛[1] 胡莹莹[1] 刘怀成[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院内分泌科卫生部内分泌重点实验,北京100730

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2008年第1期29-33,共5页Chinese Journal Of Osteoporosis And Bone Mineral Research

摘　　要：目的骨量与遗传关系紧密，FGF23是体内重要的调磷因子，但其与骨密度关系的研究还很少，因此本研究目的在于探讨中国北京汉族健康青年女性FGF23基因rs7955866位点SNP与骨密度关系。对象和方法选取202名北京汉族健康青年女性，进行血钙、磷、PTH和骨密度（BMD）检查，同时检测血DNA标本FGF23基因rs7955866位点SNP情况。结果FGF23基因型频率为CC64．4％，CT33．2％，TT2．5％，所有202名受试者经调整年龄、身高和体重后的BMD、PTH、钙和磷与FGF23等位基因无相关性。结论FGF23基因单个SNP变异与人群峰值骨量无明显直接相关。Objective Fibroblast growth factor （FGF） 23 has been identified as an crucial factor to regulate the level of phosphorus, but the relation of FGF 23 and osteoporosis is not clear. We analyzed the association between rs7955866 SNP in FGF23, and assessed genetic variant FGF23 associations with peak bone mass and others bone metabolic parameters. Subjects and methods We investigated the SNP in Exon 3 of FGF23 in 202 young women of the Han nationality in Beijing area, and collected the datas of serum Ca, P, PTH and bone mineral density. Results Hardy-Weinberg equilibrium was evident for FGF-23 gene polymorphisms. The frequency distribution of FGF23 gene were CC 64. 4%, CT 33.2%, TT 2. 5%. No significant differences in BMD at all sites, serum phosphorus, calcium and PTH levels were observed between CC, CT and Tr genotype in these young women, after adjusted by age, body and height. Conclusion Although FGF23 is a hormone to regulate the serum phosphate level, a single SNP in excon 3 of FGF23 gene could not affect the value of peak bone mass and serum phosphorus level in young women.

关 键 词：成纤维细胞生长因子23 单核苷酸多态性 骨质疏松症 骨密度 

分 类 号：Q754[生物学—分子生物学]