极低出生体重儿预防性抗真菌治疗的临床意义  

Clinical Significance and Efficacy of Preventive Anti-Fungal Treatment in Very-Low Birth-Weight Infant

作　　者：乔萍[1] 严越秀[1] 梁建红[1] 谭枝涛[1] 覃桂锋[1] 

机构地区：[1]广东省肇庆市第一人民医院新生儿科,肇庆526021

出　　处：《热带医学杂志》2008年第12期1253-1254,共2页Journal of Tropical Medicine

摘　　要：目的探讨极低出生体重儿(very low birthweight infant,VLBWI)抗真菌治疗的临床意义与疗效。方法以我科2003-2007年收治的VLBWI为研究对象,在患儿持续使用抗生素大于2～3周时给予预防性静脉抗真菌治疗(氟康唑氯化钠注射液4mg/kg·d,用2d停1d,疗程2周),观察患儿病情转归情况,监测肝、肾功能及血象情况。结果患儿病情进展较顺利,无1例出现肝、肾功能损害等副作用。结论VLBWI适时给予预防性静脉抗真菌治疗具有重要的临床意义,而且安全性较好,无明显副作用。Objective To evaluate the clinical significance of the preventive anti-fungal treatment in the prevention of fungal infection in very-low birth-weight infant. Method Very-low birth-weight infants admitted to this hospital from 2003 to 2007 were studied. Preventive anti-fongal treatment （Fluconazol 4 mg/kg/d for 2 days, followed by 1 day rest, this cycle was repeated for 2 weeks） was given to the very-low birth-weight infants receiving antibiotics for more than 2 to 3 weeks. Haematological data, liver and kidney functions were monitored after the preventive treatment. Result Side effects such as liver and kidney function failure were not observed. Conclusion Preventive anti-fungal treatment is safe in the very-low birth-weight infants.

关 键 词：极低出生体重儿 真菌 感染 预防 

分 类 号：R722.13[医药卫生—儿科]