SLE新的抗SmD1抗体检测的临床意义  

Clinical Significance of Determination of Serum Anti-SmD1 Antibody in Patients with SLE

作　　者：王奔放[1] 陈兴国[2] 王自正[2] 刘春燕[2] 曾庆娣[2] 杜同信[2] 

机构地区：[1]东南大学医学院附属江阴医院检验科,214400 [2]南京医科大学附属南京第一医院临床核医学中心,210006

出　　处：《放射免疫学杂志》2008年第6期490-492,共3页Journal of Radioimmanology

基　　金：南京医科大学自然基金面上项目(06NMUM067)

摘　　要：目的:探讨新的抗SmD1抗体检测在系统性红斑狼疮(SLE)诊断中的价值。方法:用放射免疫分析检测SLE患者血清中的抗dsDNA抗体,ELISA定量法检测抗SmD1抗体、抗Sm抗体,同时用其它风湿病患者及正常健康人血清作对照。结果:80例SLE患者抗SmD1抗体阳性率为52.5,抗Sm抗体阳性率12.5,抗dsDNA抗体阳性率33.8,80例对照组抗SmD1抗体、抗Sm抗体阳性率分别为4.0、0。结论:新的抗SmD1抗体在SLE中敏感性和特异性均较高,抗SmD1抗体可作为诊断SLE的参考指标。Objective To investigate the diagnostic value of determination of serum anti-SmD1 antibody in patients with systemic lupus erythematosus （SLE）. Mothods Serum antiSin, anti- SmD1 antibody （with ELISA） and anti-dsDNA antibody （with RIA） were detected in 80 patients with SLE and 80 controls. Results In the SLE patients, the positive rate of anti-StuD1,anti-Sm and anti-dsDNA antibody was 52.5% , 12.5% and 33.8% respectively. Among the 80 controls, 50 were patients with various kinds of other collagen diseases. Among them, the positive rate of anti-SmD1 and anti-Sm antibody was 4.0% and 0% respectively. Conclusion The diagostie sensitivity and specificity of anti - SmD1 antibody were much higher tham those of anti -Sm and anti - dsDNA antibody in patients with SLE. Anti-SmD1 antibody determination was very useful for screening of SLE sera.

关 键 词：系统性红斑狼疮 抗SMD1抗体 放射免疫分析 酶联免疫吸附分析 

分 类 号：R593.241[医药卫生—内科学] R446.62[医药卫生—临床医学]