血清及绒毛组织EGF测定在早孕及抗早孕中的应用  

Changes of Serum and Chorion-Villi Contents of EGF in Early Pregnant Women Undergone Artificial Abortion

作　　者：李素平[1] 吴晓华[1] 李慧[1] 

机构地区：[1]川北医学院附属医院核医学科,637007

出　　处：《放射免疫学杂志》2008年第6期504-506,共3页Journal of Radioimmanology

摘　　要：目的:观察早孕妇女表皮生长因子(EGF)变化,结合雌激素及孕激素测定探讨抗早孕药物米非司酮对EGF和胚胎生长的影响及其作用机理。方法:66例拟终止妊娠的早孕妇女和32例正常育龄非孕妇女分别作为早孕组和对照组,采用放射免疫分析测定血清EGF、雌二醇(E2)、孕酮(P)含量以及药物流产、人工流产绒毛组织中EGF的含量,并观察使用米非司酮后血清EGF、E2、P含量的变化。结果:早孕组血清EGF水平及E2、P明显高于对照组(P<0.01);药物流产者绒毛组织中EGF含量明显低于人工流产者(P<0.05);用米非司酮后,血清EGF和P含量均有轻度下降。结论:早孕妇女EGF升高,表明EGF对胚胎发育具有一定作用,使用米非司酮后EGF减低,提示米非司酮可能通过抑制EGF的作用对胚胎发育产生不利影响。Objective To investigate the changes of serum and chorion-villi contents of EGF in pregnant women undergone arti- ficial abortion with drug （mifepristone） or surgery （curettage）. Methods Serum epidermal growth factor （EGF）,E2,progesterone levels changes as well as chorion -villi EGF contents were measured with R/A in 36 pregnant women with drug aborbion （before and after mifepristone 25mg bid×3 days）, 30 pregnant women undergone curettage （determined twice, 3 days apart） and 32 controls （se-rum only）. Results Serum EGF, E2, and progesterone contents in all pregnant women were significantly higher than those in controls （P〈0.01）. The chorion-villi contents of EGF in patients undergone drug abortion were significantly lower than those in patients undergone curettage （P〈0.05）. Both serum EGF and progesterone contents dropped after 3 days treatment with mifepristone （ vs those in curettage group, P〈0.05）. Conclusion Mifepristone might exert the effect of abortion through docrease of EGF levels, which was detrimental to fetus growth.

关 键 词：表皮生长因子 胎儿发育 米非司酮 早孕妇女 

分 类 号：R692.505[医药卫生—泌尿科学] R169.42[医药卫生—外科学]