缺铁性贫血患者输注PRC前后血清EPO和SF水平的观察  

Observation on the Changes of Serum Erythropoietin (EPO) and Ferritin (SF) Levels After Preserved Red Cells (PRC) Transfusion in Patients with Iron Deficiency Anemia (IDA)

作　　者：李克勤[1] 吕海军[1] 李兴华[2] 

机构地区：[1]江苏省连云港市红十字中心血站,222001 [2]江苏省连云港市第一人民医院,222002

出　　处：《放射免疫学杂志》2008年第6期518-519,共2页Journal of Radioimmanology

摘　　要：目的:探讨缺铁性贫血患者输注悬浮红细胞(PRC)前后血清红细胞生成素(EPO)和铁蛋白(SF)水平的变化。方法:应用放射免疫分析对35例缺铁性贫血患者进行了输注PRC前后血清EPO和SF水平的检测,并以30名正常健康人作比较。结果:缺铁性贫血患者在输注PRC前血清EPO水平显著高于正常人组(P<0.01),而血清SF则显著低于正常人组(P<0.01);经治疗2周后血清EPO水平与正常人比较无显著性差异(P>0.05),血清SF与正常人比较仍有显著性差异(P<0.05)。结论:输注PRC对缺铁性贫血的疗效具有重要的临床价值。Objective To study the changes of serum EPO and SF levels after preserved red cells transfusion in patients with IDA. Methods Serum EPO and SF levels were detected with RIA both before and after transfusing preserved red cells in 35 patients with IDA as well as in 30 controls. Results Before transfusion senma EPO levels in the patients were significandy higher than those in the controls （ P 〈 0.01 ）, while the SF levels were significantly lower （ P 〈 0.01 ）. After a course of transfusion, the SF levels re-mained signifieandy lower than those in controls （P〈0.05）. While the EPO levels in the patients were not much different from those in controls （P〉0.05）. Conclusion Transfusing preserved red cells is an effective treatment and has important role in clinical application.

关 键 词：缺铁性贫血 悬浮红细胞 红细胞生成素 铁蛋白 

分 类 号：R556.3[医药卫生—血液循环系统疾病] R151.4[医药卫生—内科学]