血清P、HCG浓度动态检测在早期异常妊娠中的临床应用  

Clinical Usefulness of Dynamic Determination of Serum Progestrone and HCG Levels in Patients with Threatened Abortion,Inevitable Abortion and Ectopic Pregnancy

作　　者：屠凤娟[1] 丁杰锋[1] 刘琦[1] 

机构地区：[1]绍兴市妇幼保健院检验科,312000

出　　处：《放射免疫学杂志》2008年第6期524-525,共2页Journal of Radioimmanology

摘　　要：目的:探讨血清P及HCG动态检测对早期异常妊娠鉴别诊断的价值。方法:对225例早期异常妊娠患者分别进行两次(间隔48h)血清P(Progesterone,P)及HCG值,血清P值采用化学发光法测定,血清HCG浓度采用放射免疫分析。分析不同组别两者浓度变化规律。结果:先兆流产组P值明显高于难免流产组(P<0.05),异位妊娠组明显低于先兆流产组和难免流产组(P<0.01,P<0.05),先兆流产组HCG值明显高于异位妊娠组和难免流产组(P<0.05),异位妊娠组与难免流产组无显著性差异(P>0.05),但HCG上升及下降幅度<难免流产组(P<0.05)。结论:血清P及HCG动态检测对于早期异常妊娠的诊断和鉴别诊断有重要临床价值。Objective To study the clinical differential diagnostic usefulness of dynamic determinations of serum progestrone and HCG levels in patients with abortion and ectopic pregnancy. Methods Serum progestrone （with CLIA） and HCG （with RIA） levels were determined twice （48h apart） in 98 patients with threatened abortion, 75 patients with inevitable abortion, 52 patients with ectopie pregnancy, and 83 controls. Results Among the three groups of patients, the serum prngestrone levels were highest in the patients with threatened abortion, being significantly higher than those in the other two groups （P〈0. 05, P 〈 0.01 ）. The progestrone levels were low-est in the patients with eetopic pregnancy, being significantly less than those in other two groups （P〈0.05, P〈0.01）. Ther serum HCG levels were also significantly higher in the patients with threatened abortion than those in the other two groups （P 〈0.05） , but there were no significant differences between the levels in patients with inevitable abortion and patients with ectopie pregnanay. The differences be- tween the frist and second determination HCG levels, either increased or decreased, in patients with ectopie pregnancy were significantly less than those in patients with inevitable abortion （ P 〈 0.05）. Conclusion Dynamic determination of serum progesterone and HCG levels might be of differential diagnostic help in patients with threatened abortion, inevitable abortion and ectopic pregnancy.

关 键 词：孕酮 促绒毛膜性腺激素 先兆流产 难免流产 异位妊娠 

分 类 号：R714.204[医药卫生—妇产科学] R714.22[医药卫生—临床医学]