Evaluation of suspected local recurrence in lung cancer and head & neck cancer:A comparison between ^(99m)Tc-HL91 SPECT and CT for biopsy proven lesions  

作　　者：SU Xinhui SUN Long HUANG Jingxiong CHEN Guibing HE Xiaojiang LUO Zuoming PAN Weimin CHEN Qiang WU Hua 

机构地区：[1]Department of Nuclear Medicine, No. 1 Hospital of Xiamen Affiliated to Fujian Medical University, Xiamen 316003, China [2]School of Life Sciences, Xiamen University, Xiamen 316003, China

出　　处：《Nuclear Science and Techniques》2008年第6期337-342,共6页核技术（英文）

基　　金：Supported by Department of Science and Technology of Xiamen City (Grant No. 3502Z20052017).

摘　　要：CT has rather low accuracy for the follow-up of tumors after therapy. This study was to determine whether the diagnostic accuracy can be improved with 99mTc-HL91 SPECT in comparison with parallel results of CT imaging. Thirty patients of lung cancer or head & neck cancer, suspected of recurrences on clinical symptoms and CT during clinical follow-up after therapy, underwent 99mTc-HL91 SPECT. The radioactivity ratios of tumor to normal tissues (T/NT) were calculated using the region of interest technique. Results of 99mTc-HL91 SPECT were verified by histopathology. The 99mTc-HL91 average uptake ratios of T/NT in the group of recurrent lesions and non-recurrent lesions were 1.58±0.16 and 1.18±0.14, respectively. A significant difference was found between T/NT data of the two phases (t=4.87, P<0.001). The 99mTc-HL91 SPECT shows sensitivity of 72.73%, specificity of 89.47% and accuracy of 83.83% for differentiating recurrent lesion, while the CT shows sensitivity of 63.63%, specificity of 84.21% and accuracy of 76.67%. A combination of 99mTc-HL91 SPECT and CT for 21 patients with lung cancers or head & neck cancers with congruent results shows sensitivity of 100%, specificity of 94.12% and accuracy of 95.23%. It is concluded that 99mTc-HL91 SPECT may play a role in differentiating recurrent lesions in patients with lung cancer and head & neck cancer. Furthermore, the combination of CT and 99mTc-HL91 SPECT is a more effective method for diagnosing recurrence of lung cancer and head & neck cancer.CT has rather low accuracy for the follow-up of tumors after therapy. This study was to determine whether the diagnostic accuracy can be improved with ^99mTc-HL91 SPECT in comparison with parallel results of CT imaging. Thirty patients of lung cancer or head ＆ neck cancer, suspected of recurrences on clinical symptoms and CT during clinical follow-up after therapy, underwent ^99mTc-HL91 SPECT. The radioactivity ratios of tumor to normal tissues （T/NT） were calculated using the region of interest technique. Results of ^99mTc-HL91 SPECT were verified by histopathology. The ^99mTc-HL91 average uptake ratios of T/NT in the group of recurrent lesions and non-recurrent lesions were 1.58±0.16 and 1.18±0.14, respectively. A significant difference was found between T/NT data of the two phases （t=4.87, P〈0.001）. The ^99mTc-HL91 SPECT shows sensitivity of 72.73%, specificity of 89.47% and accuracy of 83.83% for differentiating recurrent lesion, while the CT shows sensitivity of 63.63%, specificity of 84.21% and accuracy of 76.67%. A combination of ^99mTc-HL91 SPECT and CT for 21 patients with lung cancers or head ＆ neck cancers with congruent results shows sensitivity of 100%, specificity of 94.12% and accuracy of 95.23%. It is concluded that ^99mTc-HL91 SPECT may play a role in differentiating recurrent lesions in patients with lung cancer and head ＆ neck cancer. Furthermore, the combination of CT and ^99mTc-HL91 SPECT is a more effective method for diagnosing recurrence of lung cancer and head ＆ neck cancer.

关 键 词：肿瘤复发 SPECT ^99MTC-HL91 CT 

分 类 号：R817.8[医药卫生—影像医学与核医学]