内皮素1在急性呼吸窘迫综合征炎症反应中的作用  

Role of endothelin-I in inflammation of acute respiratory distress syndrome

作　　者：封珊[1] 王智勇[1] 

机构地区：[1]河北医科大学第三医院ICU,石家庄050051

出　　处：《国际呼吸杂志》2008年第23期1468-1472,共5页International Journal of Respiration

摘　　要：目前认为，炎症反应是急性呼吸窘迫综合征 （acute respiratory distress syndrome, ARDS）发病的重要机制。许多研究证明，内皮素1在ARDS炎症反应中发挥促炎作用。本综述通过回顾内皮素系统的研究进展，阐述内皮素1的炎症作用在ARDS的病理生理学机制、通透性肺水肿及肺动脉高压形成中的作用，及内皮素受体拮抗剂的应用现状。Inflammatory reaction may play an important role in the pathogenesy of acute respiratory distress syndrome（ARDS）. As a number of studies have proven, the inflammatory effect of endothelin-1 （ET- 1） has been implicated in the pathophysiology of ARDS. This review will focus on the biology of ET-1 and its role as a inflammatory mediator in the pathogenesy of ARDS, the formation of pulmonary edema and pulmonary hypertension. And the recent application of endothelin receptor antagonists will be discussed.

关 键 词：内皮素1 急性呼吸窘迫综合征 炎症反应 病理生理 

分 类 号：R563[医药卫生—呼吸系统]