补肾通督方对强直性脊柱炎血清TNF-α及TGF-β_1水平的影响  

Effects of Bushen Tongdu Decoction on Serum Tumor Necrosis Factor-αand Transforming Growth Factor β_1 in Patients with Ankylosing Spondylitis

作　　者：许敬人[1] 张春燕[1] 李伟民[1] 林研[1] 茅惠明[1] 郭琛军[1] 陈翠玲[1] 

机构地区：[1]上海市东方医院,上海200120

出　　处：《中国中西医结合杂志》2008年第12期1093-1095,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：上海市卫生局资助项目(No.2005L012A)

摘　　要：目的探讨肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、转化生长因子β_1(transforming growth factorβ_1,TGF-β_1)与强直性脊柱炎(ankylosing spondylitis,AS)发病的关系及补肾通督方对AS患者血清TNF-α、TGF-β_1的影响。方法采用酶联免疫法(ELISA)对治疗Ⅰ组(30例,采用柳氮磺吡啶治疗)和治疗Ⅱ组(35例,采用补肾通督方治疗)患者治疗前及治疗24周后的TNF-α、TGF-β_1水平进行测定,并设立30名健康体检人员作为正常组。同时测定两组AS患者治疗前后的血沉(ESR)、C-反应蛋白(CRP)。结果治疗前两组患者血清TNF-α水平增高,血清TGF-β_1水平降低,与正常组比较差异有统计学意义(P<0.01),血清TNF-α水平与ESR、CRP呈正相关(r=0.296,r=0.249;P<0.05)。血清TGF-β_1水平与ESR、CRP无统计学意义相关性(r=-0.222,r=-0.203;P>0.05)。Ⅱ组治疗后,AS患者血清TNF-α水平明显降低,血清TGF-β_1水平提高,且ESR、CRP显著降低(P<0.01)。结论补肾通督方可调整AS患者血清TNF-α、TGF-β_1水平,从而抑制免疫炎症反应,达到治疗AS的作用。Objective To investigate the relationship of tumor necrosis factor-α（TNF-α） and transforming growth factor β1（TGF-β1） with the occurrence of ankylosing spondylitis （ AS）, and the effects of Bushen Tongdu Decoction （BTD） on serum TNF-a and TGF-β1 levels in patients. Methods Seventy five AS patients were assigned to two groups, 30 in the group Ⅰ treated with Azulfidine and 35 in the group Ⅱ treated with BTD. ELISA was adopted to detect the levels of TNF-α and TGF-β1 in patients before and after 24-week treatment. Meantime, erythrocyte sedimentation rate （ESR） and C-reactive protein （CRP） were measured as well. Besides, the levels of TNF-α and TGF-β1 in 30 healthy persons were also detected for normal control. Results Before treatment, as compared with normal control, the TNF-α increased and TGF-β1 decreased （P 〈 0.01 ） in the two treatment groups ; the serum level of TNF-a was positively correlated with ESR and CRP （ r = 0. 296, r = 0. 249 ; P 〈 0.05）, but the serum level of TGF-β1 showed no correlation with them （r= -0.222, r= -0.203; P〉0.05）. After treatment, TGF-β1 increased, while TNF-a, CRP and ESR decreased in group Ⅱ （P 〈0. 01）. Conclusion BTD can regulate TNF-a and TGF-β1 levels to suppress the immune inflammatory reaction so as to treat AS.

关 键 词：补肾通督方 强直性脊柱炎 肿瘤坏死因子Α 转化生长因子B. 

分 类 号：R259[医药卫生—中西医结合]