经静脉声学造影对移植肝急性排斥血流灌注的评价  

Color Doppler and contrast-enhanced ultrasonography for assessment of vascular perfusion in porcine liver allografts with acute graft rejection

作　　者：王倩[1] 龚渭冰[1] 谢金敏[1] 孙郁[1] 袁鹰[1] 

机构地区：[1]南方医科大学南方医院超声科,广东广州510515

出　　处：《南方医科大学学报》2008年第12期2251-2252,2256,共3页Journal of Southern Medical University

摘　　要：目的评价肝移植血流灌注的可行性,探讨经静脉声学造影脉冲反相谐波造影成像对移植肝急排的诊断价值。方法建立异体肝移植动物模型,采用自身前后对照,术前术后均进行外周静脉声学造影并行定量分析,同时进行肝功能监测。结果造影后急排组较未移植前及正常移植肝组AUC下降F=11.069,P=0.011;而参数A、Alpha、C、t(0)、DPI、TTP未见明显差异(P>0.05)。结论经静脉声学造影脉冲反相谐波成像技术结合声学定量技术是观测异体移植肝血流灌注的有效检测手段,此种方法所获得的TIC参数对定量估测异体移植肝排斥的发生有较高的价值。Objective To investigate the feasibility of evaluating hepatic blood perfusion after liver transplantation using color Doppler and contrast-enhanced ultrasonography and the diagnostic value of hepatic blood perfusion for acute graft rejection. Methods In this before-after study with quantitative analysis, contrast-enhanced sonography was performed with simultaneous liver function monitoring in porcine models of allograft liver transplantation before and after the operation. Results In pigs with acute graft rejection, the AUC decreased significantly after transplantation as compared with that of non-rejection transplant group （F=11.069, P=0.011）, but the parameters including A, Alpha, C, t（0）, DPI, or TIP showed no significant differences between the two groups. Conclusion Pulse-inversion contrast harmonic imaging combined with acoustic quantitative technology can be an efficient means for evaluating blood perfusion in the liver allograft, and the TIC obtained using this method possesses high values for quantitative evaluation of liver allograft rejection.

关 键 词：脉冲反相谐波成像 声学定量 异体肝移植 急性排斥 

分 类 号：R445.1[医药卫生—影像医学与核医学] R657.3[医药卫生—诊断学]