中国人醛糖还原酶基因5’端（AC）n多态性与2型糖尿病肾病相关性的meta分析  

Meta analysis on association of the 5＇-end dinucleotide repeat polymorphisms of the aldose reductase gene and susceptibility of diabetic nephropathy in Chinese patients with type 2 diabetes mellitus

作　　者：徐明彤[1] 陈筱潮[2] 严励[1] 陈维清[3] 

机构地区：[1]中山大学附属第二医院内分泌科,广州510120 [2]中山大学附属第五医院心内科 [3]中山大学公共卫生学院流行病学教研室

出　　处：《中华内分泌代谢杂志》2008年第6期623-625,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：基金项目：广东省科技计划资助项目（200583370321,2006836007005）

摘　　要：目的对中国人醛糖还原酶基因5’端（AC）n多态性与2型糖尿病合并糖尿病肾病相关性的研究进行meta分析。方法通过文献检索收集2007年4月以前发表的中国人醛糖还原酶基因5’端（AC）n多态性与2型糖尿病合并糖尿病肾病相关性的病例一对照研究，剔除不符合要求的文献，以漏斗图检验入选文献的发表偏倚，并根据各入选文献的同质性检验结果进行数据合并，计算总OR值，meta分析采用ReviewManager4．2版统计软件。结果共8篇文献符合条件纳人研究，入选文献无明显发表偏倚，各文献同质性检验显示有关Z-2（X2=18．20，P=0．01）、Z＋2（X2=35．30，P〈0．01）等位基因分布情况的文献间均存在显著异质性。Z-2等位基因增加2型糖尿病肾病的易感性（OR=1．72，95％CI1．25-2．36，P〈0．01），Z＋6等位基因对2型糖尿病患者肾脏具有保护作用（OR=0．66，95％C10．45-0.98，P=0．04），Z＋2等位基因对糖尿病肾病的易感性无影响（OR=0．73，95％C10．47—1．12，P=0．15）。结论醛糖还原酶基因5’端（AC）n多态性与中国人2型糖尿病合并糖尿病肾病易感性相关，Z～2等位基因可能是2型糖尿病患者糖尿病肾病的易感基因，Z＋6等位基因可能对2型糖尿病患者肾脏具有保护作用。Objective To evaluate the association of the 5＇-end dinucleotide repeat polymorphisms of the aldose reductase gene and susceptibility to diabetic nephropathy in Chinese patients with type 2 diabetes mellitus by means of meta analysis. Methods Genetic association studies evaluating the 5＇-end dinucleotide repeat polymorphism of the aldose reductase gene and susceptibility to diabetic nephropathy in type 2 diabetes mellitus patients involving Chinese population published before April 2007 were collected from database of PubMed, EMBASE, and CNKI. All the literatures were abstracted based on the defined selection criteria by two independent investigators. Publication bias was tested by funnel plot and the odd ratios of all studies were combined depending on the result of heterogeneity test among the individual studies. The software Review Manager （ version 4.2） was used for meta analysis. Results Eight studies involving 5＇-end dinucleotide repeat polymorphism of the aldose reductase gene and susceptibility of diabetic nephropathy in Chinese patients with type 2 diabetes mellitus met the selection criteria. There was no significant publication bias in selected studies. Heterogeneity test showed that there were significant statistic differences among the individual studies about the frequencies of Z -2 （X2 = 18.20, P = 0.01 ） and Z ＋ 2 （ X2 = 35.30, P 〈 0.01 ） allele in different groups. The combined OR of susceptibility to diabetic nephropathy in patients with Z - 2 allele was 1.72 （95 % CI 1.25-2.36, P 〈 O. 01 ） and those of Z ＋ 2 and Z ＋ 6 were 0.73 （95 % CI 0. 47-1.12, P = 0.15 ） and 0.66 （95 % C10. 45-0.98, P = 0.04） respectively. Conclusion The 5＇-end dinucleotide repeat polymorphism of the aldose reductase gene was associated with the susceptibility of diabetic nephropathy in Chinese patients with type 2 diabetes mellitus. The Z -2 allele is a genetic risk factor for diabetic nephropathy, while the Z ＋ 6 allele has protective function for kidney microvessels.

关 键 词：醛糖还原酶 糖尿病肾病 多态现象 遗传 中国人 META分析 

分 类 号：R587.2[医药卫生—内分泌] R195.1[医药卫生—内科学]