CD4＋CD25＋T细胞延长同种异体胰岛移植物存活  

CD4＋CD25＋ regulatory T cells prolong islet allografts survival

作　　者：张梅[1] 徐书杭 徐瑜[3] 刘翠萍[1] 茅晓东[1] 徐宽枫[1] 刘超[1] 

机构地区：[1]南京医科大学第一附属医院内分泌科,210029 [2]徐州矿务集团总医院内分泌科 [3]上海交通大学附属瑞金医院内分泌代谢病科

出　　处：《中华内分泌代谢杂志》2008年第6期661-663,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：基金项目：江苏省政府医学重点学科项目基金（苏卫科教2001-34）

摘　　要：为探讨CD4＋CD25＋调节性T细胞作为细胞疫苗抑制小鼠同种异体胰岛移植物排斥反应的作用，采用免疫磁珠分离技术分选CD4＋CD25＋调节性T细胞联合BALB／cByJ小鼠同种异体胰岛移植。结果显示，CD4＋CD25＋调节性T细胞可明显延长同种异体移植物的存活时间。The potential effect of donor CD4＋CD25＋ regulatory T cells on the suppression of rejection for allogenetic islet transplantation in vivo was investigated. CD4＋CD25＋ regulatory T cells were generated by magnetic activated cell sorting and were allogeneically transfered with islet transplantation in streptozotocin-induced diabetic BALB/cByJ mice. The results showed that allogeneic CD4＋CD25＋ regulatory T cells prolong islet graft survival and normoglycemia in transplanted allogeneic diabetic mice.

关 键 词：T淋巴细胞 调节性 胰岛移植 免疫耐受 

分 类 号：R657.5[医药卫生—外科学] R587.1[医药卫生—临床医学]