银屑病患者皮损内及血中神经肽(SP、SS)的研究  

Study of Substance P and Somatostatin Levels in Lesions and Seruml of Psoriasis.

作　　者：姚聪君[1] 王俊民[1] 谭升顺[1] 彭振辉[1] 

机构地区：[1]西安医科大学第二临床医学院皮肤科

出　　处：《中国皮肤性病学杂志》1998年第1期5-6,共2页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金

摘　　要：应用放射免疫分析法（ＲＩＡ）对４０例寻常性银屑病病人血及皮损中的Ｐ物质（ＳＰ）、生长抑素（ＳＳ）进行了测定，发现进行期和静止期银屑病病人皮损中ＳＰ增高，与正常人相比差异有显著性意义。ＳＰ血浆中含量、ＳＳ血及皮损中含量均与正常人无显著差别。结果提示：ＳＰ可能通过局部作用参与银屑病的病理过程，ＳＳ可能对银屑病的病理改变无影响。这也提示有必要开发安全、可靠的ＳＰ拮抗剂来治疗银屑病。In this investigation,the levels of substance P(SP) and Somatostatin (SS) in Plasma and skin lesions of 40 psoriasis vulgaris patients and that of 30 normal persons were measured by radioimmunoassay(RIA).The content of SP in lesions of active and stable psoriasis increased significantly comparing with that in recovery patients and normal cases(P<0.05).Sp and SS levels in Plasma and skin lesions had no notable difference between two groups (P>0.05).All these suggested SP may participate the histopathologic process of psoriasis locally.It was probably a major factor in the occurance development and maintenance of psoriasis lesions.We can be infered to study utilize more safe and effective SP antagonist to treat Psoriasis.

关 键 词：P物质 生长抑素 银屑病 RIA 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]