颅痛定对心肌缺血-再灌注性室性心律失常及血浆内皮素-1浓度的影响  

Effects of rotundine on ventricular arrhythmias and endothelin1 concentration in plasma during myocardial ischemiareperfusion

作　　者：马建群[1] 毛焕元[1] 曹林生[1] 曾秋棠[1] 冯义柏[1] 程龙献[1] 吴桂芳[1] 毛奕[1] 

机构地区：[1]同济医科大学心血管病研究所

出　　处：《中国危重病急救医学》1998年第1期7-9,共3页Chinese Critical Care Medicine

摘　　要：目的：观察颅痛定对心肌缺血再灌注性室性心律失常及血浆内皮素１浓度的影响。方法：利用１４只硫喷妥钠静脉麻醉开胸犬结扎左前降支冠状动脉（ＬＡＤ）４０分钟，继以再灌注４０分钟进行研究。随机分成颅痛定组（７只）和对照组（７只）。持续心电监护并记录室性心律失常发生情况。２组均在缺血前、缺血１０、２０和４０分钟及再灌注１０、２０和４０分钟时，采集右心房血并测定血浆内皮素１浓度。结果：颅痛定能显著降低缺血再灌注性室性心律失常的发生率和血浆内皮素１浓度。与对照组比较有显著性差异（Ｐ＜０．０５和Ｐ＜０．０１）。结论：颅痛定具有良好的抗心肌缺血再灌注性室性心律失常的作用，其机制可能与降低血浆内皮素１浓度有关。Objective:To observe the effects of rotundine on ventricular arrhythmias(VA) and endothelin1 concentration in plasma during myocardial ischemiareperfusion.Methods:After intravenous Pentothal anesthesia,14 dogs with openchest were underwent 40 minutes occlusion of the left anterior descending coronary artery followed by 40 minutes of reperfusion.Dogs were randomly divided into rotundine group (n=7) and control group (n=7).Continuous cardioelectrographic monitoring was performed and ventricular arrhythmias were recorded.Right atrium blood samples were collected before ischemia,at 10,20,40 minutes during ischemia,and at 10,20 and 40 minutes during reperfusion in both groups.Plasma endothelin1 concentrations were measured.Results:Rotundine significantly reduced incidences of VA and plasma endothelin1 concentrations compared to the controls during myocardial ischemia and reperfusion (P<005～001).Conclusions:Rotundine may have good effect on antiventricular arrhythmia induced by myocardial ischemia and reperfusion,which may be associated with reduction of plasma endothelin1 concentration.

关 键 词：颅痛定 缺血 再灌注损伤 心律失常 内皮素 

分 类 号：R541.7[医药卫生—心血管疾病]