牡丹皮流浸膏对实验性癫痫及小鼠自发活动的影响  

Antiepileptic action and inhibition of autonomic activity of extract of moutan cortex in mice

作　　者：王瑜[1] 明亮[1] 章家胜[1] 岑德意[1] 王宏光[1] 王翠芳 董六一[1] 

机构地区：[1]安徽医科大学药理教研室

出　　处：《安徽医科大学学报》1998年第1期8-10,共3页Acta Universitatis Medicinalis Anhui

基　　金：安徽省教委科研基金

摘　　要：目的研究牡丹皮流浸膏（ｅｘｔｒａｃｔｏｆｍｏｕｔａｎｃｏｒｔｅｘ，ＥＭＣ）对多种实验性癫痫模型及小鼠自发活动的影响。方法采用最大电惊厥（ｍａｘｉｍａｌｅｌｅｃｔｒｏｓｈｏｃｋｓｅｉｚｕｒｅ，ＭＥＳ）及戊四唑、士的宁、氨基脲等惊厥模型。结果ＥＭＣ（１１，相当于生药量３７５ｍｇｋｇ－１，５００ｍｇｋｇ－１，ｉｇ）可剂量依赖性对抗小鼠ＭＥＳ及戊四唑、士的宁、氨基脲所致小鼠惊厥作用。ＥＭＣ作用峰时为１～２ｈ；ＥＭＣ（２５０ｍｇｋｇ－１）可增强苯巴比妥抗ＭＥＳ作用。此外ＥＭＣ（２５０ｍｇｋｇ－１，ｉｇ）可剂量依赖性抑制小鼠自发活动。结论ＥＭＣ具有明显抗癫痫作用并可抑制小鼠自发活动。Objective The effects of the extract of moutan cortex on experimental seizures and autonomic activity were studied in mice. Methods The maximal electroshock seizure(MES), and the seizures induced by metrazol, strychnine or semcarbazide were applied in this paper. Results EMC(375￣500 mg·kg-1,ig) had a dosedependent protective effects against MES in mice, and could antagonize the seizures induced by metrazol, strychnine, semcarbazide, and enhance protective effects of phenobarbital against MES in mice. Its peak time was at 1￣2 h after administration. In addition, it was also observed that EMC could reduce numbers of autonomic activity dosedependently in mice. Conclusions EMC had significantly antiepileptic activity and inhibitory effect of autonomic activity.

关 键 词：癫痫 中医药疗法 牡丹皮流浸膏 动物实验 

分 类 号：R277.721[医药卫生—中医学] R285.5