云芝多糖提高实验性动脉粥样硬化家兔抗氧化能力和减轻主动脉粥样硬化斑块  

Polysacchride Krestin elevates the tissue antioxidative potentiality and alleviates the aortic atherosclerotic plaque area of experimental atherosclerotic rabbits

作　　者：欧阳谦[1] 刘翠华[1] 陈瑗[1] 周玫[1] 刘尚喜[1] 娄宁[1] 

机构地区：[1]第一军医大学自由基医学研究室,广州510515

出　　处：《第一军医大学学报》1998年第1期8-11,共4页Journal of First Military Medical University

基　　金：国家自然科学基金

摘　　要：为研究云芝多糖（PSK）对实验性动脉粥样硬化家兔的治疗作用，以新西兰纯种家兔制成实验性动脉粥样硬化模型后，观察了PSK对组织抗氧化能力和主动脉粥样硬化斑块的影响。结果：PSK能有效降低心、肝、颈总动脉脂质过氧化物含量，提高组织含硒谷胱甘肽过氧化物酶活性和mRNA含量，使主动脉粥样硬化斑块减少465％，显著降低胸主动脉和腹主动脉内壁粥样斑块面积和各分支开口处斑块形成数，PSK治疗组心壁内冠状动脉大、中分支的狭窄程度也明显少于对照组。In this study,in order to further illustrate the effects of polysacchride Ksestin (PSK) on the antioxidative potential ity of tissues and the formation of aortic atherosclerotic plaque of experimental atherosclerotic rabbits, we mimicked atherosclerosis in rabbits,then treated them with PSK. We found that PSK could decrease the lipid peroxide (LPO) level and elevate the SeGSHPx activity and mRNA level in the heart and liver, especially enhance the antioxidative potentiality in these tissues. Moreover,the results also showed that the atherosclerotic plaque area in rabbits treated with PSK decreased by 46. 5 % as compared with that in control group.And furthermore,the number of plaques at the small arterial opening in the thoracic aorta and abdominal aorta of the PSK group was less than that of the control group. And the cross sections at the upper one-third of heart showed that the degree of stenosis of the branches of coronary arteries in the heart wall of the PSK groupwas much less than that of the control group. The present results provided a further experimental basis for the clinical usage of PSK.

关 键 词：云芝多糖 动脉粥样硬化 脂质过氧化 OLDL 

分 类 号：R543.505[医药卫生—心血管疾病] R979.5[医药卫生—内科学]