不同剂量rhIL-1β保护γ线照射小鼠的实验研究  

Experimental study on the protective effect of rhIL-1β on mice exposed to acute radiation

作　　者：谭筱江[1] 凌世淦[2] 邬梦麒[1] 刘久山[1] 

机构地区：[1]第一军医大学南方医院呼吸科,广州510515 [2]军事医学科学院三所,北京100850

出　　处：《第一军医大学学报》1998年第1期56-58,共3页Journal of First Military Medical University

摘　　要：以60Coγ射线照射小鼠为模型，研究了rhIL－1β不同剂量对照射小鼠造血恢复的影响。结果给予不同剂量rhIL－1β（3×103u／鼠～3×105u／鼠）后可使6．5Gy照射小鼠外周血白细胞、红细胞及血小板的恢复明显加快，照后10d骨髓CFU－GM、BFU－E及BFU－Meg含量随给药剂量加大而增加。表明rhIL－1β能促进照射小鼠的造血功能恢复。In order to study the protective effect of rhIL-1β on mice exposed to acute radiation,different doses of recombinant human interleukin-1β (rhIL-1β) were given to Amms/5 inbred mice irradiated with 6.5 Gy 60Co γ-ray and the protective effect of rhIL-1β on the hemopoietic recovery was evaluated. It was shown that the recovery of the peripheral WBC, RBC and platelet counts was much quicker in the groups of mice pretreated with rhIL-1β than in the untreated ones. The CFU-GM.BFU-E and BFU-Meg in the bone marrow on the 10th day postradiation all increased with increasing dose of rhIL-1β. The results demonstrate that rhIL-1β can promote the recovery of hemopoiesis in irradiated animals.

关 键 词：γhIL-1β 白细胞介素1Β 造血细胞 剂量 

分 类 号：R331.14[医药卫生—人体生理学] R815.2[医药卫生—基础医学]