Osthol和Icarin对甲减小鼠血清甲状腺激素的影响  

Effects of osthol and icariin on serum thyroid hormone in mice of hypothyroidism type kidneyyang insufficiency

作　　者：秦路平[1,2,3,4] 石汉平[1,2,3,4] 郑水庆 李博华 洪求兵 王洪斌 张家庆 

机构地区：[1]第二军医大学药学院生药学教研室 [2]第一军医大学南方医院普通外科 [3]第二军医大学药学院药理学教研室 [4]第二军医大学长海医院内分泌科

出　　处：《第二军医大学学报》1998年第1期48-50,共3页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金

摘　　要：目的：观察蛇床子素（Ｏｓｔｈｏｌ）和淫羊藿甙（Ｉｃａｒｉｎ）对甲减“肾阳虚”小鼠血清甲状腺激素的影响。方法：用丙基硫氧嘧啶（ＰＴＵ）制备甲减“肾阳虚”小鼠模型，用放射免疫法测定小鼠血清Ｔ３、ｒＴ３和Ｔ４的浓度。结果：模型鼠血清Ｔ３、ｒＴ３和Ｔ４浓度皆降低（Ｐ＜０．０１），死亡率升高（Ｐ＜０．０１），造模过程中同时分别给药Ｏｓｔｈｏｌ和Ｉｃａｒｉｎ能有效地阻止Ｔ３、ｒＴ３和Ｔ４浓度下降（Ｐ＜０．０１或Ｐ＜０．０５），死亡率也显著降低（Ｐ＜０．０１）。同时模型鼠分别经Ｏｓｔｈｏｌ和Ｉｃａｒｉｎ治疗后，Ｔ３、ｒＴ３和Ｔ４浓度得到明显提高（Ｐ＜０．０１或Ｐ＜０．０５）。结论：Ｏｓｔｈｏｌ和Ｉｃａｒｉｎ既能拮抗ＰＴＵ的甲状腺抑制作用，预防“肾阳虚”证的出现，又能促进ＰＴＵ所致甲减“肾阳虚”小鼠体内甲状腺激素水平的提高，具有补肾壮阳作用。Objective: To observe the effects of osthol and icariin on serum thyroid hormone in mice of kidneyyang insufficiency. Methods: The mice model of hypothyroidism type kidenyyang insufficiency was induced by propylthiouracili (PTU). Osthol and icariin were administered orally to the model mice, and the serum contents of T3, rT3 and T4 were determined by the method of RIA. Results: As compared with that of normal mice, the serum contents of T3, rT3 and T4 in model mice lowered (P<0.01), and mortality increased significantly (P<0.01). When administered respectively with PTU, both osthol and icariin could effectively prevent the decrease of thyroid hormone and the increase of mortality (P<0.05 or P<0.01). When the model mice were treated by osthol and icariin separately, the serum contents of T3, rT3 and T4 were raised obviously (P<0.05 or P<0.01). Conclusion: Both osthol and icariin can antagonize the inhibition of PTU on thyroid, and improve the recovery of thyroid hormone in the mice of hypothyroidism type kidneyyang insufficiency induced by PTU, showing the effects of reinforcing kidneyyang.

关 键 词：蛇床子素 淫羊藿甙 甲状腺机能减退 中国 

分 类 号：R259.812[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]