遵义地区人群激素敏感性脂肪酶基因第6内含子多态性与2型糖尿病的关系  

The correlation of the hsl gene polymorphism and T2DM in Zunyi region

作　　者：李学英[1] 葛斌[1] 路健[1] 王大忠[1] 

机构地区：[1]遵义医学院细胞生物学与遗传学教研室,贵州省563003

出　　处：《中国糖尿病杂志》2008年第12期721-722,共2页Chinese Journal of Diabetes

基　　金：遵义市科学技术项目遵义科合字(2004)22号

摘　　要：目的探讨遵义地区人群激素敏感性脂肪酶基因(hsl)第6内含子(i6)多态性与2型糖尿病(T2DM)的关系。方法采用聚合酶链式反应-单链构象多态性方法,检测247例中国遵义地区人群hsli6多态性,其中T2DM患者130例,正常对照(NC)117名。结果hsli6等位基因5、9在T2DM组和NC组的频数分布差异有统计学意义(P<0.05)。结论遵义地区正常糖耐量人群与T2DM人群之间hsli6第5、第9等位基因分布频率可能存在统计学差异。Objective To explore the relationship between the polyrnorphism of intron 6（i6） of hormone sensitive lipase （HSL） gene and type 2 diabetes mellitus （T2DM） in the population of Zunyi region. Methods Polymorphism of the hsl i6 was examined by ploymerase chain reaction- single strand conformation polymorphism （PCR-SSCP） in 130 patients with T2DM and 117 nondiabetic healthy subjects in the Zunyi population. Results The frequency of the allele 5 and 9 had significant difference between T2DM and the normal group（P〈0. 05）. Conclusions The distribution differences in the allele 5 and 9 frequency of hsl i6 may have statistical significance between the normal subjects and type 2 diabetes in Zunyi region.

关 键 词：糖尿病 2型 激素敏感性脂肪酶 多态性 基因 

分 类 号：R587.1[医药卫生—内分泌]