糖尿病对大鼠脑内葡萄糖转运蛋白表达的影响  

Effect of diabetes on expression of glucose transporters in rat brain

作　　者：李大伟[1] 赵晓民[1] 张玲[1] 蔡洪信[1] 夏青[2] 杨明峰[1] 夏作理[1] 

机构地区：[1]泰山医学院脑微循环重点实验室,山东泰安271000 [2]北京大学药学部

出　　处：《中国糖尿病杂志》2008年第12期755-756,共2页Chinese Journal of Diabetes

摘　　要：目的探讨糖尿病(DM)对大鼠脑内葡萄糖转运蛋白1(GluT-1)和GluT-3表达的影响。方法应用免疫荧光检测DM大鼠脑内海马和皮质部位GluT-1和GluT-3表达情况。结果正常组大鼠海马部位GluT-1和GluT-3表达多于皮质部位。DM组大鼠脑内GluT-1表达减少(P<0.01),GluT-3表达在海马部位有所增加(P<0.01),皮质部位无明显变化(P>0.05)。结论糖尿病引起脑内GluT-1和GluT-3表达水平变化,继而脑内葡萄糖转运发生相应变化以适应脑内能量代谢。Objective To explore the effect of diabetes on expression of glucose transporter 1,and 3 （GluT 1 and 3）. Methods After the successful establishment of diabetic rat model, immunofluorescence method was applied to detect the expressions of GluT-1 and 3 in cerebral hippocampus and cortex in rats. Results In normal rat brain, there were much more expressions of GluT-1 and 3 both in hippocampus and in cortex（P〈0.01）. However, the expression of GluT-1 decreased, and the expression of GluT-3 increased in hippocampus （P〈0. 01）, but unchanged in cortex in the diabetic rat brain （P〉0. 05）. Conclusions DM changes the expression levels of GluT-1 and 3, then the brain glucose transportation changes accordingly so as to accommodate the brain energy metabolism.

关 键 词：糖尿病 大鼠 葡萄糖转运蛋白 

分 类 号：R587.1[医药卫生—内分泌] R245[医药卫生—内科学]