冠状动脉粥样硬化性心脏病合并糖尿病患者冠状动脉病变与C反应蛋白的相关性研究  

Research on relationship between C-reactive protein level and coronary artery pathologic change in patients with coronary artery disease and diabetes mellitus

作　　者：钱家琦[1] 熊龙根[1] 江中喜[1] 

机构地区：[1]广州医学院附属第二医院心内科广州心血管疾病研究所,广东广州510260

出　　处：《国际内科学杂志》2008年第12期690-691,738,共3页International Journal of Internal Medicine

摘　　要：目的探讨冠状动脉粥样硬化性心脏病(简称冠心病)合并糖尿病患者冠状动脉病变程度与高敏C反应蛋白(hsCRP)的关系。方法接受冠状动脉造影检查的患者161例进入此研究,冠心病但血糖正常组52例,冠心病伴有糖耐量异常组24例,冠心病合并2型糖尿病组85例。记录各组临床资料、冠状动脉造影评分,并检测各组患者血浆hsCRP水平。结果冠心病合并2型糖尿病组冠状动脉造影评分明显高于血糖正常组,差异有统计学意义(P<0.01);冠心病合并2型糖尿病组患者hsCRP水平明显高于血糖正常组(P<0.01)。冠状动脉造影评分与hsCRP水平之间呈正相关(r=0.309)。结论冠心病合并糖尿病患者的冠状动脉病变严重程度与血浆hsCRP水平正相关。Objective To explore the relationship between high sensitive C-reactive protein （hsCRP） and coronary angiographic score in patients with coronary artery disease（CAD） and diabetes mellitus. Methods One hundred and sixty one patients with CAD undergoing coronary angiography were divided into three groups ： CAD without diabetes group（52 cases） ;CAD with impaired glucose tolerance group（24 cases） ; CAD with type 2 diabetes group（ 85 cases）. The coronary angiograpbie score and clinical data were recorded, and hsCRP level of patients was detected. Results The coronary angiographic score and hsCRP level of CAD with type 2 diabetes patients were significantly higher than that of CAD without diabetes patients（P 〈0.01 ）. The coronary angiographic score had positive correlation with hsCRP level in patients with CAD and diabetes（ r =0. 309）. Conclusion The severity of coronary artery disease in patients with CAD and type 2 diabetes was positively correlated with the plasma hsCRP level of patients.

关 键 词：冠状动脉疾病 糖尿病 高敏C反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]