白细胞介素-32免疫学特征及与HIV的相关性研究  

The immunological functions of Interleukin-32 and its correlation with HIV

作　　者：王婧[1] 路慧丽[1] 韩伟[1] 

机构地区：[1]上海交通大学药学院再生医药学研究室,上海200240

出　　处：《现代生物医学进展》2008年第12期2586-2588,共3页Progress in Modern Biomedicine

摘　　要：白细胞介素-32(IL-32)是近年来新发现的前炎症反应细胞因子,在体内分布广泛,而且作用呈多样化,除了具有诱导多种细胞因子产生,导致前炎症反应和自身免疫病,上调TNF-α的表达,介导T细胞活化诱导死亡等作用外,IL-32还可以抑制人类免疫缺陷病毒的复制,增强机体的自然防御能力,因而在疾病预防和治疗方面有重要意义。本文根据国内外的研究结果,综述了IL-32的免疫生物学特征及与HIV的相关性研究。Interleukin-32 is a recently identified pro-inflammatory cytokine, which is widely spread in vivo and affects many kinds of cytokines. Except inducing many kinds of cytokines, causing the pro-inflammation and autoimmune diseases, up-regulating the expression and secretion of TNF-α, inducting the activation-induced cell death in T cells, IL-32 suppresses human immunodeficiency virus （HIV） replication. IL-32 plays a vital role in prevention and treatment of some diseases. In this review, IL-32 will be illustrated from the aspects of molecular structure, and the immunologic functions IL-32 and the correlation with HIV.

关 键 词：白细胞介素-32 前炎症反应因子 人类免疫缺陷病毒(HIV) 

分 类 号：R392.11[医药卫生—免疫学]