动态脉压水平与2型糖尿病肾损害程度的关系  

Relationship between the dynamic pulse pressure level and the renal injury extent in type 2 diabetic patients

作　　者：刘斌[1] 王连春[1] 李贵森[2] 李焱鑫[3] 林家弟[1] 蔡雁朗[1] 

机构地区：[1]四川省人民医院心血管超声及心功能检查科,成都610072 [2]四川省人民医院肾脏内科,成都610072 [3]四川省人民医院检验科,成都610072

出　　处：《临床内科杂志》2008年第12期827-829,共3页Journal of Clinical Internal Medicine

摘　　要：目的探讨不同脉压水平与糖尿病患者肾功能损害的关系。方法测量239例糖尿病患者的动态血压,根据有无合并高血压分成正常组(A组)和合并高血压组(B组)。每组根据24小时动态脉压水平不同分为3个亚组。分析脉压与糖尿病病程、体重指数、24小时平均收缩压、24小时平均舒张压、空腹血糖、总胆固醇、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、甘油三酯的关系以及PP与肾功能指标血尿素(BUN)、血肌酐(Cr)、尿α1微球蛋白、尿微球白蛋白、尿转铁蛋白、尿免疫球蛋白的关系。结果随着脉压差的增大,尿α1微球蛋白、尿微球白蛋白、尿转铁蛋白、尿免疫球蛋白在两个分组中比较均有显著差异性,肾功能损害指标与脉压正相关。结论脉压与肾功能损害关系密切,及早进行干预,降低收缩压的同时防止舒张压过度降低减少脉压增大,对降低肾损害起到积极作用。Objective To observe the relationship between the dynamic pulse pressure （PP） and the renal injury in type 2 diabetic patients. Methods Two hundred and thirty-nine type 2 diabetic patients received ambulatory blood pressure monitor for 24 hours were divided into 2 groups with or without hypertension, and each group was further divided into 3 sub-groups based on pulse pressure level of PP 〈 50 mm Hg, PP = 50-70 mm Hg and PP 〉 70 mm Hg. Some parameters including urinary Uα1 M, Trfu, IgGu, Aide were compared among the sub-groups. Result Significant differences were showed in Uα1,IgGu,Albu,Trfu between the two groups as the pulse pressure increases. Conclusion Close correlation is found between pulse pressure and renal injury and pulse pressure is valuable in reflecting renal injury in diabetic patients.

关 键 词：动态脉压 2型糖尿病 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]