T型钙通道对心脏功能的调节作用  

Roles of T-type calcium channels in the regulation of cardiac function

作　　者：金松南[1] 文今福[1] 金景玉[2] 曹景宇[1] 

机构地区：[1]泰山医学院,泰安271000 [2]青岛大学医学院,青岛266021

出　　处：《生命的化学》2008年第6期782-785,共4页Chemistry of Life

基　　金：国家自然科学基金(30570669);山东省卫生系统中青年重点科技人才资助项目资助

摘　　要：T型钙通道存在于心血管、神经和内分泌系统。T型钙通道在心脏自律性、细胞生长和心脏重塑中起关键性的作用。心脏疾病时T型钙通道表达增多。因此T型钙通道在生理和病理生理情况下均可参与心脏功能的调节。随着对钙通道研究的日益加深,可望更深刻地了解T型钙通道并研制出新的钙通道拮抗剂,这对心脏疾病的治疗策略具有重要的意义。T-type Ca^2＋ channels are present in cardiovascular, neuronal, and endocrine systems. In the heart, T-type Ca^2＋ channels play important roles in heart automaticity, cell growth, and cardiac remodeling. The expression of T-type Ca^2＋ channels are shown to be increased in diseased heart. Thus, T-type Ca^2＋ channels might be involved in physiological and/or pathophysiological modulations of the cardiac function. Selective inhibitors of T-type Ca^2＋ channels may lead to the development of novel therapeutic strategies for diseased heart.

关 键 词：T型钙通道 MIBEFRADIL 心脏功能 心房钠尿肽 

分 类 号：Q46[生物学—生理学]