冠心病患者支架植入术前后hs-CRP变化及氟伐他汀的干预作用  

Change of hs -CRP Levels in Serum of Coronary Heart Disease Patients with Angioplasty and the Effect of Fluvastatin

作　　者：焦云根[1] 

机构地区：[1]东南大学心血管病研究所江苏省扬州市第一人民医院心内科,江苏扬州225001

出　　处：《中国现代医生》2008年第36期26-27,共2页China Modern Doctor

摘　　要：目的观察冠状动脉内支架成形术治疗冠心病患者手术前后血清hs-CRP含量的变化,以及术后使用氟伐他汀对其的影响。方法冠心病患者64例,随机分为治疗组(术后24h在常规治疗基础上加用氟伐他汀)32例和对照组(仅常规治疗)32例。采用免疫浊度法动态观察不同时间点血清hs-CRP含量。结果两组患者术后血清hs-CRP含量显著升高(P<0.05);术后8周治疗组hs-CRP显著降低(P<0.001),两组比较有显著性差异(P<0.001)。结论冠状动脉内支架植入术可致血清hs-CRP升高,氟伐他汀可降低血清hs-CRP含量,具有抗炎、稳定斑块的作用。Objective To observe the change of hyper sensitive C-reactive protein（hs-CRP） content in serum of patients with coronary heart disease for angioplasty and to evaluate the therapeutic effect of fluvastatin on it. Methods Totally 64 cases of coronary heart disease treated with stent were randomly divided into therapy group （n=32,general therapy plus fluvastatin 24h after angioplasty） and control group （n=32, general therapy without fluvastatin）. Hs-CRP levels in serum was observed dynamically by immune turbidity method at different time points before and after angioplasty. Results Hs-CRP levels in serum increased significantly after angioplasty in both groups（P〈 0.05） 8 weeks after angioplasty,hs-CRP was decreased significantly in therapy group （P 〈 0.001 vs control group）. Conclusion Angioplasty may lead to the increase of hs-CRP level in serum, but fluvastatin can down-regulate the level, so it has the role of anti-inflammatory.

关 键 词：支架植入术 冠心病 C反应蛋白 氟伐他汀 

分 类 号：R541.4[医药卫生—心血管疾病]