早孕期母血清产前筛查标志物初始中位数研究  

The initial medians of maternal serum marker in the first trimester prenatal screening

作　　者：王珏[1] 孙丽洲[1] 曹郡[1] 孙筱[1] 

机构地区：[1]南京医科大学第一附属医院江苏省妇幼卫生保健中心,江苏南京210036

出　　处：《中国优生与遗传杂志》2008年第11期54-55,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的通过对253例早孕期母血清产前筛查资料进行回顾性分析,建立本地人群的初始参数。方法采用时间分辨免疫荧光检测技术,对我院孕10-13周的253例孕妇进行产前筛查标志物妊娠相关血浆蛋白A(PAPP-A)、游离β人绒毛促性腺激素(freeβ-HCG)检测,并利用非线性回归拟合方程计算孕天初始中位数。结果建立了本筛查中心孕早期PAPP-A、freeβ-HCG的初始中位数,其孕周变化趋势与软件内嵌参数一致,与国内相关报道数据接近。结论种族、实验室系统性偏差对孕妇筛查标志物的预期(正常)中位数浓度有影响,各实验室应首先建立自己的初始中位数,以保证产前筛查结果的可靠性。Objective ： To set the initial medians of local population by retrospectively assey 253 samples of first trimester prenatal screening. Methods： Dissociation enhanced lanthanide fluoroimmunoassay system was used to detect the maternal serum markers in 253 pregnant women at about 10 - 13 week of gestation - pregnancy - associatedplasma protein A （ PAPP - A ） , free beta - human chorionic gonadotrnpin （freeβ- HCG）. And derive the day -specific median by nonlinear regression. Results： The center normal medians of PAPP - A and freeβ - HCG in first - trimester had been set up. The changing tendency with gestational age was in accord- ance with the original parameter inserted in software. The initial medians approach the data reported by inland literatures. Conclusion： The factors of race and systematic differences between laboratories can influence the expected （normal） median concentration of maternal serum markers, so each laboratory should establish its own median in order to improve the confidence in prenatal screening results.

关 键 词：产前筛查 妊娠相关血浆蛋白A 游离β人绒毛促性腺激素 初始中位数 

分 类 号：R714.5[医药卫生—妇产科学]