黏着斑激酶与细胞迁移  

Focal Adhesion Kinase and Cell Migration

作　　者：安君艳[1] 张晓岚[1] 

机构地区：[1]河北医科大学第二医院河北省消化病研究所,河北省重点实验室,石家庄050000

出　　处：《细胞生物学杂志》2008年第6期707-710,共4页Chinese Journal of Cell Biology

基　　金：河北省自然科学基金资助项目(No.C2008001133)~~

摘　　要：细胞迁移过程始于细胞前端板状伪足的形成、外周黏附的建立、细胞体的收缩和尾部的解离。黏着斑激酶是一种非受体酪氨酸蛋白激酶,通过其激酶活性和"脚手架"的功能在细胞迁移的各个过程中发挥关键作用。现重点介绍黏着斑激酶介导的信号转导通路及其在调控细胞迁移方面的研究进展。The process of cell migration is initiated by protrusion at the leading edge of the cell, the formation of peripheral adhesions, the exertion of force on these adhesions, and finally the release of the adhesions at the rear of the cell. Focal adhesion kinase is intimately involved in the regulation of this process through its kinase activity and its function as a scaffolding molecule. This review focus is limited to the signal transduction pathways mediated by focal adhesion kinase and its role in regulation of cell migration.

关 键 词：黏着斑激酶 细胞迁移 信号通路 

分 类 号：Q25[生物学—细胞生物学]