盘基网柄菌多细胞体大小调节中细胞计数因子的研究  

Cell Counting Factor and Its Regulation on the Size of Multicell in Dictyostelium discoideum

作　　者：杨春霞[1] 李丽[1] 杨硕[1] 王大磊[1] 侯连生[1] 

机构地区：[1]华东师范大学生命科学学院,上海200062

出　　处：《细胞生物学杂志》2008年第6期727-730,共4页Chinese Journal of Cell Biology

基　　金：国家自然科学基金项目资助(No.30470226)~~

摘　　要：在盘基网柄菌发育过程中,通过细胞计数机制来调节发育中盘基网柄菌多细胞体的大小。计数因子是由countin、CF50、CF45-1等亚基组成的活性分子,在多细胞体大小调节中有着重要作用。现对计数因子的各亚基及其功能,以及它通过cAMP信号途径、糖代谢途径、AKt/PKB信号途径协同调控子实体大小的作用机制进行综述。During the development of Dictyostelium discoideum, the size of multicell is regulated by counting mechanism. The cell number counting factor （CF） is a bioactive molecule composed of countin, CF50, CF45-1 and other subunits, and have important effects on the regulation of cells body size. This article review these subunits and their functions, and the mechanism of cAMP pulse, glycometabolic pathway, AKt/PKB pathway involved in regulation of CF.

关 键 词：计数因子 子实体 cAMP脉冲 AKt/PKB途径 

分 类 号：Q2[生物学—细胞生物学]