Age-related changes of serum tartrate-resistant acid phosphatase 5b and the relationship with bone mineral density in Chinese women  

作　　者：Yue-juan QIN Zhen-lin ZHANG Hao ZHANG Wei-wei HU Yu-juan LIU Yun-qiu HU Miao LI Jie-mei GU Jin-wei HE 

机构地区：[1]The Department of Osteoporosis, Osteoporosis Research Unit, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China [2]Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA

出　　处：《Acta Pharmacologica Sinica》2008年第12期1493-1498,共6页中国药理学报（英文版）

基　　金：Project was supported by National Natural Science Foundation of China （No 30570891, 30771019）, Hospital Alliance Foundation and Program of Shanghai Subject Chief Scientist （No08XD14030）.Acknowledgement We thank 2 anonymous reviewers for comments that improved the manuscript and will aid our future research.

摘　　要：Aim： Osteoclastic activity is mainly assessed by measurement of urinary markers （eg C-terminal cross-linked telopeptides of type I collagen, N-terminal cross- linked telopeptides of type I collagen etc）, the levels of which could often be affected by renal clearance. Recently, serum tartrate-resistant acid phosphatase 5b （TRACP5b） has been used as an alternative serum marker to evaluate osteoclastic activity. We investigated the age-related changes of TRACP5b level and its association with bone mineral density （BMD） in Chinese women. Methods： Seven-hundred and twenty-two Chinese mainland women aged 20-79 years were recruited in the study. Serum TRACP5b level was measured using immunoassay to evaluate the state of bone resorption. Bone mineral density （BMD） （g/cm^2） at lumbar spine 1-4 and proximal femur were measured by duelenergy X-ray absorptiometry. Results： The serum TRACP5b level reached a bottom value in premenopausal women aged 30-39, gradually increased in women aged 40-49, rapidly rose in women aged 50-59, and culminated with a maximum value in women aged 60-69 before a slow drop in women aged 70- 79. The average level of TRACP5b was significantly higher in postmenopausal women [（3.29±1.07） U/L] than in premenopausal women （[1.70±0.59] U/L）. The levels of TRACP5b were inversely correlated with BMD at all measured sites （P〈0.001）. Furthermore, the level of TRACP5b was obviously higher in women with osteoporosis and osteopenia than those with normal bone mass （P〈0.001）. Conclusion： We have established the reference values of serum TRACP5b in Chinese mainland women, and found TRACP5b concentration than younger that postmenopausal women had higher women. The results showed that serum TRACP5b was a sensitive and useful parameter for the evaluation of age-related changes of bone absorption.Aim： Osteoclastic activity is mainly assessed by measurement of urinary markers （eg C-terminal cross-linked telopeptides of type I collagen, N-terminal cross- linked telopeptides of type I collagen etc）, the levels of which could often be affected by renal clearance. Recently, serum tartrate-resistant acid phosphatase 5b （TRACP5b） has been used as an alternative serum marker to evaluate osteoclastic activity. We investigated the age-related changes of TRACP5b level and its association with bone mineral density （BMD） in Chinese women. Methods： Seven-hundred and twenty-two Chinese mainland women aged 20-79 years were recruited in the study. Serum TRACP5b level was measured using immunoassay to evaluate the state of bone resorption. Bone mineral density （BMD） （g/cm^2） at lumbar spine 1-4 and proximal femur were measured by duelenergy X-ray absorptiometry. Results： The serum TRACP5b level reached a bottom value in premenopausal women aged 30-39, gradually increased in women aged 40-49, rapidly rose in women aged 50-59, and culminated with a maximum value in women aged 60-69 before a slow drop in women aged 70- 79. The average level of TRACP5b was significantly higher in postmenopausal women [（3.29±1.07） U/L] than in premenopausal women （[1.70±0.59] U/L）. The levels of TRACP5b were inversely correlated with BMD at all measured sites （P〈0.001）. Furthermore, the level of TRACP5b was obviously higher in women with osteoporosis and osteopenia than those with normal bone mass （P〈0.001）. Conclusion： We have established the reference values of serum TRACP5b in Chinese mainland women, and found TRACP5b concentration than younger that postmenopausal women had higher women. The results showed that serum TRACP5b was a sensitive and useful parameter for the evaluation of age-related changes of bone absorption.

关 键 词：TRACP5B bone turnover bone mineral density 

分 类 号：R457[医药卫生—治疗学]