醋柳黄酮缓释片的药动学初步研究  

Study of pharmacokinetics of sustained-release tablets of TFH

作　　者：蔡源源[1] 孙华[2] 王玮[1] 杨栋[1] 王攀[1] 

机构地区：[1]河南大学药学院药剂教研室,河南开封475004 [2]河南大学第一附属医院药剂科,河南开封475004

出　　处：《河南大学学报（医学版）》2008年第4期36-38,50,共4页Journal of Henan University:Medical Science

基　　金：河南省教育厅自然科学研究计划项目(2006350002)

摘　　要：目的:研究醋柳黄酮缓释片在家犬体内的药动学过程,测定其药动学参数,计算缓释片相对于普通片的生物利用度。方法:将实验动物分为两组,分别用醋柳黄酮缓释片和普通片进行口服给药,用高效液相色谱法测定血浆药物浓度,应用3P97软件求算药动学参数。结果:醋柳黄酮缓释片及普通片的tm ax分别为4.87 h和2.87 h,Cm ax分别为每小时0.46μg.L-1和每小时0.56μg.L-1,缓释片的相对生物利用度为111.7%。结论:醋柳黄酮缓释片与普通片均符合一室模型,缓释片与普通片具有生物等效性,且醋柳黄酮缓释片有明显的缓释效果。Objective： To research the pharmacokinetical process of TFH sustained-release tablets in dogs and to determine its pharmaeokinetieal parameters, in order to calculate relative bioavailability of the sustained-release tablets. Methods： Experimental animals were divided into two groups, which were orally administered TFH sustained-release tablets and the reference tablets respectively, the plasma concentration of TFH was determined by HPLC and the pharmacokineties parameters were calculated by 3P97 Program. Results： The top time of TFH sustained-release tablets and the reference tablets were 4.87 h and 2.87 h, the C were 0.56 and 0.56μg ml^-1, the bioavailability of sustained Release Tablets was 111.7%. Conclusion： The profile of TFH sustained-release tablets and reference tablets in the dogs fit to one compartment model, TFH sustained-release tablets and tablets are bioequivalent, and TFH sustained-release tablets have obvious feature to release sustained.

关 键 词：醋柳黄酮 缓释片 高效液相色谱法 药动学 

分 类 号：R969[医药卫生—药理学]