2-^(18)F-2-脱氧-β-D-葡萄糖的自动化合成研究  

Automated synthesis of 2—[^(18)F]—fluoro-2-deoxy-D-glucose

作　　者：范文博[1] 彭添兴[1] 颜和平[1] 

机构地区：[1]厦门市第一医院核医学科PET中心,福建厦门361003

出　　处：《应用化工》2008年第12期1462-1464,共3页Applied Chemical Industry

摘　　要：采用TRACERlab FXF-N自动化合成装置制备了肿瘤显像剂2-18F-2-脱氧-β-D-葡萄糖(18F-FDG)。以三氟甘露糖为前体,在同一反应瓶中经过亲核氟化、氢氧化钠水解两步反应,然后用小柱分离纯化制备了18F-FDG注射液。同时还研究了亲核取代氟化反应体系中的含水量和前体三氟甘露糖的用量对合成效率的影响。结果表明,18F-FDG总合成时间约25 min,未校正18F衰变情况下,放射化学产率约55%,放射化学纯度大于98%。Automated synthesis of 2-[ ^18F]-fluoro-2-deoxy-D-glucose （^18F-FDG） was performed by twostep reaction procedure at TRACERlab FXF-N system,^18F-FDG injection was obtained via two-step reaction including nucleophilic fluorination of the precursor 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfony- β-D-mannopyranose with ^18F-fluoride and hydrolysis with NaOH in the same reaction vessel, and subsequently purificated with Sep-Pak cartridges. The influence factors of synthesis yield were investigated. ^18F-FDG was performed with the uncorrected radiochemical yield about 55% and radiochemical purity above 98% within the total synthesis time about 25 min.

关 键 词：肿瘤显像剂 化学合成 ^18F-FDG 自动化 

分 类 号：TQ426[化学工程]