苯氧布洛芬钙的合成新工艺  

A New Synthesis Process of Fenoprofen Calcium

作　　者：胡金清[1] 楼良弟[1,2] 钟光祥[1] 

机构地区：[1]浙江工业大学药学院,杭州310032 [2]巨化集团公司制药厂,浙江衢州324004

出　　处：《化工生产与技术》2008年第6期20-22,共3页Chemical Production and Technology

摘　　要：以间羟基苯乙酮、溴苯为起始原料,经过醚化、Darzens缩合、水解、氧化等反应制得苯氧布洛芬,最后转化为钙盐,总收率38.8%,并以核磁共振仪和红外光谱仪确认了产物。与传统工艺相比,具有成本低、反应温和、易操作的优点。Fenoprofen was synthesized from m-hydroxyacetophenone and bromobenzene by etherification,darzens condensation,hydrolyzation and oxidation. Fenoprofen calcium was generated from fenoprofen by salification with an overall yield of about 38.8%. The product was confirmed by NMR spectrometer and IR spectrometer. Comparing with traditional process,this method is advance in low cost,mild reaction and easy operation.

关 键 词：苯氧布洛芬钙 苯氧布洛芬 间羟基苯乙酮 溴苯 合成 

分 类 号：Z87[文化科学]