口腔用奥硝唑微球的制备研究  

Preparation of ornidazole microspheres for oral use

作　　者：刘霞[1] 

机构地区：[1]天津市口腔医院,天津300041

出　　处：《天津药学》2008年第6期28-31,共4页Tianjin Pharmacy

摘　　要：目的:以奥硝唑为主药,以乳酸-羟基乙酸共聚物(PLGA)为包裹材料,探索释药时间为7 d的微球的制备方法并优化工艺。方法:采用液中干燥法制备奥硝唑微球,考查搅拌速度、PVA浓度和PLGA浓度对微球粒径的影响,以紫外分光光度法测定微球中奥硝唑的含量及奥硝唑从微球的释放。结果:通过控制不同的因素可以得到释药时间为7 d的微球,测得的载药量及包封率符合药典规定。结论:采用液中干燥法通过控制不同的因素可以得到释药周期为7 d的奥硝唑缓释微球。OBJECTIVE Aim to study the method of preparation of omidazole mierospheres which PLGA is the parcel material. To explore the technique of process optimization which the release time within seven days. METHODS Mierospheres were prepared using a drying technique in liquid. Study the stirring speed , the concentration of PVA and the concentration of PLGA to affect the particle size. The concentration of ornidazole and the releasing of omidazole were determined by ultraviolet speetrophotometry method. RESULTS Smooth mierospheres which the release time within seven days could be produced by controlling different process pa- rameter. The loading and encapsulation rate of omidazole meet the requirements of pharmacopoeia. CONCLUSION The desirable omidazole mierospheres which the release time within seven days can be prepared using a drying technique in liquid by controlled different process.

关 键 词：生物可降解性微球 乳酸-羟乙酸共聚物 液中干燥法 奥硝唑 

分 类 号：R944.2[医药卫生—药剂学]