肝胃宁对大鼠胃粘膜的保护作用及临床研究  

Rat and clinical studies of Gan_wei_ning on gastric mucosal protection

作　　者：刘菲[1] 陆玮[1] 陆震宇 王莉[1] 

机构地区：[1]上海医科大学附属华山医院消化科,上海200040

出　　处：《中国新药与临床杂志》1998年第1期20-22,共3页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :探讨肝胃宁对胃粘膜的保护作用。方法 :大鼠 35只 ,♀♂不限 ,2 0 0～ 30 0 g ,随机分为正常对照组、无水乙醇对照组及肝胃宁预防组。分别以 0 .9%氯化钠溶液 1mL、0 .9%氯化钠溶液 1mL、肝胃宁 1mL灌胃 ,2h后再分别以 0 .9%氯化钠溶液 1mL、无水乙醇 1mL、无水乙醇 1mL灌胃。再过 2h后麻醉 ,抽血 ,处死取胃 ,进行大体、光镜、电镜、Na+_K+_ATPase活性、胃酸及血内皮素、前列腺素测定。临床治疗慢性胃炎 (糜烂型 ) ,以肝胃宁 2 0g ,tid× 8wk。结果 :肝胃宁能增强胃粘膜Na+_K+_ATPase活力 ,增加胃粘膜前列腺素及降低血内皮素 ,但不影响胃酸分泌。对大鼠胃粘膜损伤有保护作用。肝胃宁治疗慢性胃炎 (糜烂型 )取得较好疗效。结论AIM: To study the protective effect of Gan_wei_ning (GWN) on gastric mucosa. METHODS: Rat experiment: 35 rats were randomly divided into A) saline, B) absolute EtOH, and C) GWN+EtOH. All rats were fasted for 24 h and deprivated of water for 2 h before the experiment. 1 mL of saline was given to Group A and Group B and 1 mL of oral solution of GWN to Group C. After 2 h, 1 mL of 0.9% sodium chloride was given to Group A and 1 mL of EtOH was given to Group B and C. Two hours later, their stomachs were taken out and the gastric mucosa was observed by macroscopy, optical microscope and electron microscope, and Na +_K +_ATPase of gastric mucosa, homogenate, gastric acid, endothelin (ET) and 6_keto prostaglandin F 1α in serum were determined. Clinical study: Patients with gastritis were treated with GWN 20 g, po, tid×8 wk. RESULTS: GWN enhanced the activity of Na +_K +_ATPase, increased PG level, and reduced ET level in serum, but did not affect the secretion of gastric acid. The gastric mucosal injury in Group C was obviously milder than that in Group A. CONCLUSION: GWN has protective effect on gastric mucosa.

关 键 词：肝胃宁 胃粘膜 保护作用 慢性胃炎 

分 类 号：R975[医药卫生—药品] R573.305[医药卫生—药学]